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Monoclonal IgE-mediated cardiac hypersensitivity reactions in the guinea-pig

  • Allergy, Histamine and Kinins
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Abstract

Isolated heart preparations were prepared from guinea-pigs passively sensitized with mouse anti-DNP monoclonal IgE to study hemodynamic parameters and histamine release upon antigen challenge (DNP-BSA). In the best experimental conditions a triphasic response (increase, decrease, increase) in heart rate and in coronary flow occurred during 10 minutes after challenge. Coronary flow dramatically decreased (50%) at 2.5 min flanked by two periods of increase in flow and tachycardia (+55% of the basal heart rate). Contractile force decreased and remained at 80% of its initial value. Histamine is released within 2 minutes after antigen injection. After this period, the observed hemodynamic modifications seem to be due to other anaphylactic mediators such as prostaglandins, leukotrienes and most probably paf-acether.

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Authors and Affiliations

  1. INSERM U.200, 32 rue des Carnets, 92140, Clamart, France

    Y. Denizot, J. Boudet, C. Burtin, I. Marro & J. Benveniste

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  1. Y. Denizot
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  2. J. Boudet
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  3. C. Burtin
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  4. I. Marro
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  5. J. Benveniste
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Denizot, Y., Boudet, J., Burtin, C. et al. Monoclonal IgE-mediated cardiac hypersensitivity reactions in the guinea-pig. Agents and Actions 29, 167–171 (1990). https://doi.org/10.1007/BF01966442

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  • DOI: https://doi.org/10.1007/BF01966442

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