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Circadian variation in urinary melatonin in clinically healthy women in Japan and the United States of America

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Summary

Urinary melatonin excretion is lower in East-Asian (Japanese) than in North-American (whites of mixed ethnic origin) women. Moreover, a statistically significant circadian rhythm is demonstrated by population-mean cosinor in the data pool from both groups of women. Furthermore, statistical significance characterizes interactions of effects from geographic differences (between ethnic groups) with temporal factors. Such spatio-temporal interactions await further scrutiny with a view inter alia of carcinogenesis as it is influenced by a spectrum of intermodulating rhythms.

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Authors and Affiliations

  1. Chronobiology Laboratories, Department of Laboratory Medicine and Pathology, University of Minnesota, 55455, Minneapolis, Minnesota, USA

    L. Wetterberg, F. Halberg, B. Tarquini, M. Cagnoni, E. Haus, K. Griffith, T. Kawasaki, Lee-Anne Wallach, Michio Ueno, K. Uezo, M. Matsuoka, Marilyn Kuzel, Erna Halberg & T. Omae

  2. Department of Psychiatry, Karolinska Institute, St Göran's Hospital, S-11281, Stockholm, Sweden

    L. Wetterberg, F. Halberg, B. Tarquini, M. Cagnoni, E. Haus, K. Griffith, T. Kawasaki, Lee-Anne Wallach, Michio Ueno, K. Uezo, M. Matsuoka, Marilyn Kuzel, Erna Halberg & T. Omae

  3. Department of Medicine, University of Florence, Florence, Italy

    L. Wetterberg, F. Halberg, B. Tarquini, M. Cagnoni, E. Haus, K. Griffith, T. Kawasaki, Lee-Anne Wallach, Michio Ueno, K. Uezo, M. Matsuoka, Marilyn Kuzel, Erna Halberg & T. Omae

  4. Tenovus Institute, Welsh National University, Cardiff, Wales, UK

    L. Wetterberg, F. Halberg, B. Tarquini, M. Cagnoni, E. Haus, K. Griffith, T. Kawasaki, Lee-Anne Wallach, Michio Ueno, K. Uezo, M. Matsuoka, Marilyn Kuzel, Erna Halberg & T. Omae

  5. 2nd Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka City, Japan

    L. Wetterberg, F. Halberg, B. Tarquini, M. Cagnoni, E. Haus, K. Griffith, T. Kawasaki, Lee-Anne Wallach, Michio Ueno, K. Uezo, M. Matsuoka, Marilyn Kuzel, Erna Halberg & T. Omae

  6. St Paul-Ramsey Hospital, 55101, St Paul, Minnesota, USA

    L. Wetterberg, F. Halberg, B. Tarquini, M. Cagnoni, E. Haus, K. Griffith, T. Kawasaki, Lee-Anne Wallach, Michio Ueno, K. Uezo, M. Matsuoka, Marilyn Kuzel, Erna Halberg & T. Omae

Authors
  1. L. Wetterberg
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  2. F. Halberg
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  3. B. Tarquini
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  4. M. Cagnoni
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  5. E. Haus
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  6. K. Griffith
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  7. T. Kawasaki
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  8. Lee-Anne Wallach
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  9. Michio Ueno
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  10. K. Uezo
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  11. M. Matsuoka
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  12. Marilyn Kuzel
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  13. Erna Halberg
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  14. T. Omae
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Additional information

Supported by U.S. Public Health Service (5-K6-GM-13981-17), National Cancer Institute (1R01-CA-14445-05 and N01-CP-5-5702), National Institute of Occupational Safety and Health (OH-00631-01), National Institute of Aging (AG-00158), Environmental Protection Agency (R804513-01-0), Swedish Medical Research Council grant 3371 and the St Paul Ramsey Medical Research and Education Foundation. R.B. Sothern and Jung-Keun Lee, Scientists, Chronobiology Laboratories, University of Minnesota provided valuable help.

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Wetterberg, L., Halberg, F., Tarquini, B. et al. Circadian variation in urinary melatonin in clinically healthy women in Japan and the United States of America. Experientia 35, 416–419 (1979). https://doi.org/10.1007/BF01964386

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  • DOI: https://doi.org/10.1007/BF01964386

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