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Epoetin alfa in anaemic children or adolescents on regular dialysis

  • Nephrology/Urology
  • Published:
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Abstract

Eighteen patients aged 5–18 years on regular dialysis had a packed cell volume (PCV)<0.27. On treatment with epoetin alfa (EA) PCV increased by 0.05 or more in all patients. Iron supplementation was necessary in 13 patients with a ferritinaemia <300 μg/l before study. During treatment, plasma potassium increased significantly and more vigorous antihypertensive measures were required in 8 patients, 5 of them being already on antihypertensive drugs before EA. Iliofemoral thrombosis occurred in 1 patient 10 days after renal transplant. The data indicate that EA ameliorates the anaemia of chronic renal disease. The main concerns arising during treatment with EA are hyperkalaemia, arterial hypertension and possibly thrombosis.

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Abbreviations

EA:

epoetin alfa

PCV:

packed cell volume

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Authors and Affiliations

  1. Inselspital, University Children's Hospital, CH-3010, Berne, Switzerland

    M. G. Bianchetti, C. Roduit & O. H. Oetliker

  2. University Children's Hospital, Zürich, Switzerland

    I. Hämmerli, T. J. Neuhaus & E. P. Leumann

Authors
  1. M. G. Bianchetti
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  2. I. Hämmerli
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  3. C. Roduit
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  4. T. J. Neuhaus
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  5. E. P. Leumann
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  6. O. H. Oetliker
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Bianchetti, M.G., Hämmerli, I., Roduit, C. et al. Epoetin alfa in anaemic children or adolescents on regular dialysis. Eur J Pediatr 150, 509–512 (1991). https://doi.org/10.1007/BF01958435

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  • DOI: https://doi.org/10.1007/BF01958435

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