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Epidermal growth factor receptors and prognosis in primary breast cancer

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Abstract

A retrospective study was performed on 109 human breast tumors stored in liquid nitrogen in order to assess the prognostic value of epidermal growth factor receptor (EGF-R) (median patient follow-up 5 years). A significant inverse relationship was observed between EGF-R and both estrogen (ER) and progesterone receptors (PR). Univariate analysis showed a trend towards a shorter metastasis-free survival both in the overall population and in node-negative patients with EGF-R positive tumors. Multivariate analysis of the overall population showed that lymph-node involvement and PR status were the only significant variables in predicting metastasis-free survival. However, in patients receiving no adjuvant treatment (hormone therapy or chemotherapy), EGF was the only significant variable in the multivariate Cox analysis. No c-erbB-1 amplification was detected in these tumors.

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Authors and Affiliations

  1. Laboratoire des récepteurs hormonaux, Centre René Huguenin, 35 rue Dailly, 92211, Saint-Cloud, France

    Frédérique Spyratos & Catherine Andrieu

  2. Laboratoire d'oncovirologie, Centre René Huguenin, 92211, Saint-Cloud, France

    Rosette Lidereau & Marie-Hélène Champème

  3. Département de statistiques médicales, Centre René Huguenin, 92211, Saint-Cloud, France

    Kamel Hacène & Maurice Brunet

  4. Département de chirurgie, Centre René Huguenin, 92211, Saint-Cloud, France

    Maurice Brunet

  5. Institut Gustave Roussy, 94800, Villejuif, France

    Jean-Claude Delarue

Authors
  1. Frédérique Spyratos
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  2. Jean-Claude Delarue
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  3. Catherine Andrieu
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  4. Rosette Lidereau
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  5. Marie-Hélène Champème
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  6. Kamel Hacène
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  7. Maurice Brunet
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Spyratos, F., Delarue, JC., Andrieu, C. et al. Epidermal growth factor receptors and prognosis in primary breast cancer. Breast Cancer Res Tr 17, 83–89 (1990). https://doi.org/10.1007/BF01806288

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