Skip to main content
SpringerLink
Log in

Is sepsis a mediator-inhibitor mismatch?

  • Original
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864–874

    Google Scholar 

  2. Bone RC (1992) Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA 268:3452–3455

    Google Scholar 

  3. Bone RC (1993) Gram-negative sepsis: a dilemma of modern medicine. Clin Mibrobiol Rev 6:57–68

    Google Scholar 

  4. Matuschak G, Rinaldo J (1988) Organ interactions in the ARDS during sepsis. Role of the liver in host defense. Chest 94:401–406

    Google Scholar 

  5. Welbourn CRB, Young Y (1992) Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators. Br J Surg 79:998–1003

    Google Scholar 

  6. Parrilo JE (1993) Pathogenetic mechanisms of septic shock. N Engl J Med 328:1471–1477

    Google Scholar 

  7. Cipolle MD, Pasquale MD, Cerra FB (1993) Secondary organ dysfunction. From clinical perspectives to molecular mediators. Crit Care Clin 9:261–298

    Google Scholar 

  8. Strieter RM, Lynch JP, Basha MA, Standiford TJ, Kasahara K, Kunkel SL (1990) Host responses in mediating sepsis and adult respiratory distress syndrome. Semin Respir Infect 5:233–247

    Google Scholar 

  9. Manthous CA, Hall JB, Samsel RW (1993) Endotoxin in human disease. Part 1. Biochemistry, assay and possible role in diverse disease states. Chest 104:1572–1581

    Google Scholar 

  10. Bone RC (1994) Gram-positive organisms and sepsis. Arch Intern Med 154:2634

    Google Scholar 

  11. Gardinali M, Padalino P, Vesconi S et al (1992) Complement activation and polymorphonuclear neutrophil leukocyte elastase in sepsis. Correlation with severity of disease. Arch Surg 127(10): 1219–1224

    Google Scholar 

  12. Monick M, Glazier J, Hunninghake GW (1987) Human alveolar macrophages suppress interleukin-1 (IL-1) activity via the secretion of prostaglandin E2. Am Rev Respir Dis 135:72–77

    Google Scholar 

  13. Manthous CA, Hall JB, Samsel RW (1993) Endotoxin in human disease. Part 2. Biologic effects and clinical evaluations of antiendotoxin therapies. Chest 104:1872–1881

    Google Scholar 

  14. Bruin KF, von der Möhlen MAM, van Deventer SJH (1994) Endotoxemia and sepsis: important roles for lipopolysaccharides, binding proteins and CD 14 in endotoxin signal transduction. In: Reinhart K, Eyrich K, Sprung C (eds) Sepsis. Current perspectives in pathophysiology and therapy. Springer. Berlin, pp 53–60

    Google Scholar 

  15. Kirikae T, Lei MG, Chen TY, Morrison DC (1994) Interactions of endotoxin with membranes and membrane receptors. In: Brigham K (ed) Endotoxin and the lungs. Marcel Dekker, New York, pp 21–44

    Google Scholar 

  16. Martin TR, Tobias PS, Mathison JC, Ulevitch RJ (1994) Interactions between endotoxin and endotoxin-binding protein. In: Brigham K (ed) Endotoxin and the lungs. Marcel Dekker, New York, pp 45–67

    Google Scholar 

  17. Schumann RR, Lamping N, Kirschning C, Knopf HP, Hoess A, Hermann F (1994) Lipopolysaccharide binding proteins: its role and therapeutical potential in inflammation and sepsis. Biochem Soc Trans 22:80–83

    Google Scholar 

  18. Tracey KJ, Cerami A (1993) Tumor necrosis factor: an update review of its biology. Crit Care Med 21:S415-S422

    Google Scholar 

  19. Beutler B, Grau GE (1993) Tumor necrosis factor in the pathogenesis of infectious disease. Crit Care Med 21: S423-S435

    Google Scholar 

  20. Dunn DL (1991) Role of endotoxin and host cytokines in septic shock. Chest 100:164S-168S

    Google Scholar 

  21. Ghosh S, Latimer R, Gray BM, Harwood RJ, Oduro A (1993) Endotoxin-induced organ injury. Crit Care Med 21:S19-S24

    Google Scholar 

  22. Marks JD, Marks CB, Luce JM et al (1990) Plasma tumor necrosis factor in patients with septic shock. Am Rev Respir Dis 141:94–97

    Google Scholar 

  23. Damas P, Reuter A, Gysen P, Demonty J, Lamy M, Franchimont P (1989) Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 17:975–978

    Google Scholar 

  24. Dinarello CA, Gelfand JA, Wolff SM (1993) Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 269: 1829–1835

    Google Scholar 

  25. de Wall J, Malefyt R, Abrams J, Bennett B, Figdor CC, de Vries JE (1991) Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulary role for IL-10 produced by monocytes. J Exp Med 174:1209–1220

    Google Scholar 

  26. Marchant A, Devière J, Byl B, De Groote D, Vincent JL, Goldman M (1994) Interleukin-10 production during septicaemia. Lancet 343:707–708

    Google Scholar 

  27. Exley AR, Cohen J, Buurman W et al (1990) Monoclonal antibody to TNF in severe septic shock. Lancet 335: 1275–1277

    Google Scholar 

  28. Fisher CJ, Opal SM, Dhainaut JF et al (1993) Influence of an anti-tumor necrosis monoclonal antibody on cytokine levels in patients with sepsis. Crit Care Med 21:318–327

    Google Scholar 

  29. Fisher CJ Jr, Slotman GJ, Opal SM et al (1994) Ihitial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of septic syndrome: a randomized, open-label, placebo-controlled, multicenter trial. Crit Care Med 22:12–21

    Google Scholar 

  30. Mantovani A, Bussolino F, Dejana E (1992) Cytokines regulation of endothelial cell function. FASEB J 6: 2591–2599

    Google Scholar 

  31. Osborn L (1990) Leukocyte adhesion to endothelium in inflammation. Cells 62:3–6

    Google Scholar 

  32. Gee MH, Albertine KH (1993) Neutrophil-endothelial cell interactions in the lung. Ann Rev Physiol 55:227–248

    Google Scholar 

  33. Malik AB (1993) Endothelial cell interactions and integrins. New Horizons 1:37–51

    Google Scholar 

  34. Adams DH, Shaw S (1994) Leucocyte-endothelial interactions and regulation of leucocyte migration. Lancet 343: 831–836

    Google Scholar 

  35. Kilbourn RG, Belloni P (1990) Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. J Nath Cancer Inst 82:772–776

    Google Scholar 

  36. Vallance P, Moncada S (1993) Role of endogenous nitric oxide in septic shock. New Horizons 1:77–86

    Google Scholar 

  37. Moncada S, Palmer R, Higgs E (1991) Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43:109–142

    Google Scholar 

  38. Ochoa JB, Udekura OA, Billiar TR et al (1991) Nitrogen oxide levels in patients following trauma and during sepsis. Ann Surg 214:621–626

    Google Scholar 

  39. Lorente JA, Landin L, De Pablo R et al (1993) L-arginine pathway in the sepsis syndrome. Crit Care Med 21: 1287–1295

    Google Scholar 

  40. Anggard E (1994) Nitric oxide: mediator, murderer, and medicine. Lancet 343:1199–1206

    Google Scholar 

  41. Freeman B (1994) Free radical chemistry of nitric oxide. Looking at the dark side. Chest 105:79S-84S

    Google Scholar 

  42. Klebanoff SJ (1988) Phagocytic cells: products of oxygen metabolism. In: Gallin JI, Goldstein JM, Snyderman R (eds) Inflammation: basic principles and clinical correlates. Raven Press, New York, pp 391–444

    Google Scholar 

  43. Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320: 365–375

    Google Scholar 

  44. Zimmerman GA, Prescott SM, McIntyre TM (1992) Endothelial cell interactions with granulocytes: tethering and signaling molecules. Immunol Today 13:93–99

    Google Scholar 

  45. Ward PA (1991) Mechanisms of endothelial cell killing by H2O2 or products of activated neutrophils. Am J Med 91 [Suppl 3 c]:89S-94S

    Google Scholar 

  46. Zimmerman JJ (1992) Oxyradical pathogenesis in sepsis. Mediators of sepsis. In: Lamy M, Thys LG (eds) Update in intensive care and emergency medicine, vol 16. Springer, Berlin, pp 136–151

    Google Scholar 

  47. Kretzschmar M (1994) Role of oxygen free radicals in the pathophysiology of sepsis. In: Reinhart K, Eyrich K, Sprung C (eds) Sepsis. Current perspectives in pathophysiology and therapy. Springer, Berlin, pp 122–135

    Google Scholar 

  48. Goode HF, Webster NR (1993) Free radicals and antioxidants in sepsis. Crit Care Med 21:1770–1776

    Google Scholar 

  49. Nahum A, Chamberlin W, Sznajder JI (1991) Differential activation of mixed venous and arterial neutrophils in patients with sepsis syndrome and acute lung injury. Am Rev Respir Dis 143:1083–1087

    Google Scholar 

  50. Sznajder JL, Fraiman A, Hall JB et al (1989) Increased hydrogen peroxide in the expired breath of patients with acute hypoxemia respiratory failure. Chest 96:606–612

    Google Scholar 

  51. Bertrand Y, Pincemail J, Hannique G et al (1989) Differences in tocopherol-lipid ratio in ARDS and no ARDS patients. Intensive Care Med 15:87–93

    Google Scholar 

  52. Pacht ER, Timerman AP, Lykens MG, Merola AJ (1991) Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome. Chest 100:1397–1403

    Google Scholar 

  53. Leff JA, Parsons PE, Day CE et al (1993) Serum antioxidants as predictors of adult respiratory distress syndrome in patients with sepsis. Lancet 341: 777–780

    Google Scholar 

  54. Levi M, Ten Cate H, van der Poll T, van Deventer SJH (1993) Pathogenesis of disseminated intravascular coagulation in sepsis. JAMA 270:975–979

    Google Scholar 

  55. Koltai M, Hosford D, Braquet P (1993) Platelet-activating factor in septic shock. New Horizons 1:87–95

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anaesthesiology and Intensive Care, Centre for the Biochemistry of Oxygen, CHU, Domaine Universitaire du Sart Tilman, B.P. 35, B-4000, Liege 1, Belgium

    M. Lamy & G. Deby-Dupont

Authors
  1. M. Lamy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Deby-Dupont
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lamy, M., Deby-Dupont, G. Is sepsis a mediator-inhibitor mismatch?. Intensive Care Med 21 (Suppl 2), S250–S257 (1995). https://doi.org/10.1007/BF01740763

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01740763

Keywords

Search

Navigation