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Antigenic analysis of type O foot-and-mouth disease virus in the persistently infected bovine

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Summary

The antigenic profiles of serotype O strains of FMDV collected from the oropharynx of persistently infected cattle were defined with a panel of monoclonal antibodies (mAb's) in an indirect antigen-trapping ELISA. The mAb profiling showed no significant loss of reactivity in two neutralising antigenic sites of persistent FMDV isolates collected over a period of eight months. Early and late serum taken from a carrier animal showed similar neutralising activity against early and late carrier isolates. The antigenic stability of serotype O strains of FMDV collected during the carrier state suggests that antigenic variation facilitated by pressure from the host humoral immune response is not critical to the establishment or maintenance of a persistent infection with FMDV.

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  1. Pirbright Laboratory, Institute for Animal Health, Pirbright, UK

    J. S. Salt, A. R. Samuel & R. P. Kitching

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Salt, J.S., Samuel, A.R. & Kitching, R.P. Antigenic analysis of type O foot-and-mouth disease virus in the persistently infected bovine. Archives of Virology 141, 1407–1421 (1996). https://doi.org/10.1007/BF01718244

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  • DOI: https://doi.org/10.1007/BF01718244

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