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Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest?

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Abstract

Objective

To determine the role of cerebral vasoconstriction in the delayed hypoperfusion phase in comatose patients after cardiac arrest.

Design

Prospective study.

Setting

Medical intensive care unit in a university hospital.

Patients

10 comatose patients (Glasgow Coma Score ≤6) successfully resuscitated from a cardiac arrest occurring outside the hospital.

Measurements

We measured the pulsatility index (PI) and mean blood flow velocity (MFV) of the middle cerebral artery, the cerebral oxygen extraction ratio and jugular bulb levels of endothelin, nitrate, and cGMP during the first 24 h after cardiac arrest.

Results

The PI decreased significantly from 1.86±1.02 to 1.05±0.22 (p=0.03). The MFV increased significantly from 29±10 to 62±25 cm/s (p=0.003). Cerebral oxygen extraction ratio decreased also from 0.39±0.13 to 0.24±0.11 (p=0.015). Endothelin levels were high but did not change during the study period. Nitrate levels varied widely and showed a slight but significant decrease from 37.1 μmol/l (median; 25th–75th percentiles: 26.8–61.6) to 31.3 μmol/l (22.1–39.6) (p=0.04). Cyclic guanosine monophosphate levels increased significantly from 2.95 nmol/l (median; 25th–75th percentiles: 2.48–5.43) to 7.5 nmol/l (6.2–14.0) (p=0.02).

Conclusions

We found evidence of increased cerebrovascular resistance during the first 24 h after cardiac arrest with persistent high endothelin levels, gradually decreasing nitrate levels, and gradually increasing cGMP levels. This suggests that active cerebral vasoconstriction due to an imbalance between local vasodilators and vasoconstrictors plays a role in the delayed hypoperfusion phase.

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Authors and Affiliations

  1. Medical Intensive Care Unit (Department of General Internal Medicine), University Hospital Leiden, Building 1 C6-Q, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    G. Buunk, J. G. van der Hoeven & A. E. Meinders

  2. Department of Clinical Chemistry, University Hospital Leiden, The Netherlands

    M. Frölich

Authors
  1. G. Buunk
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  2. J. G. van der Hoeven
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  3. A. E. Meinders
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  4. M. Frölich
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Buunk, G., van der Hoeven, J.G., Meinders, A.E. et al. Cerebral vasoconstriction in comatose patients resuscitated from a cardiac arrest?. Intensive Care Med 22, 1191–1196 (1996). https://doi.org/10.1007/BF01709335

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  • DOI: https://doi.org/10.1007/BF01709335

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