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Comparison of the nucleoprotein genes of a chicken and a mink influenza A H 10 virus

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Summary

The base sequences of the coding region of the nucleoprotein (NP) genes of two H 10 influenza A viruses, one avian (virus N) and one mink virus, have been determined by primer extension. When the NP genes and the NP sequences derived from the only open reading frame of the two H 10 viruses were compared with those of other human and avian influenza A viruses, it turned out that the mink virus NP was highly related to that of other avian strains, but differed from that of the human strains. Comparison of the NP genes of the mink and avian strains of European origin suggests a direct lineage between them. Since the NP plays a major role in species specificity, it is assumed that an avian influenza virus has directly invaded the mink population.

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References

  1. Bean WJ (1984) Correlation of influenza A virus nucleoprotein genes with host specificities. Virology 133: 438–442

    Google Scholar 

  2. Bean WJ, Hinshaw WS, Webster RG (1981) Genetic characterization of an influenza virus from seals. In: Bishop DHL, Compans RW (eds) The replication of negative strand viruses. Elsevier/North-Holland, New York Amsterdam Oxford, pp 363–367

    Google Scholar 

  3. Becht H, Malole B (1975) Comparative evaluation of different fixation procedures and different coupling reagents for the demonstration of influenza virus-specific antibodies by the indirect hemagglutination test. Med Microbiol Immunol 162: 43–53

    Google Scholar 

  4. Buckler-White AJ, Murphy BR (1986) Nucleotide sequence analysis of the nucleoprotein gene of an avian and a human influenza virus strain identifies two classes of nucleoproteins. Virology 155: 348–355

    Google Scholar 

  5. Geraci JR, St Aubin DJ, Barker IK, Webster RG, Hinshaw VS, Bean WJ, Ruhnke HL, Prescott JH, Early G, Baker AS, Madoff S, Schooly RT (1982) Mass mortality of harbor seals: pneumonia associated with influenza A virus. Science 215: 1129–1131

    Google Scholar 

  6. Hinshaw VS, Webster RG (1982) The natural history of influenza A viruses. In: Beare AS (ed) Basic and applied influenza research. CRC Press, Boca Raton, Florida, pp 79–104

    Google Scholar 

  7. Huddleston JA, Brownlee GG (1982) The sequence of the nucleoprotein gene of human influenza A virus strain A/NT/60/68. Nucleic Acids Res 10: 1029–1038

    Google Scholar 

  8. Klingeborn B, Englund L, Rott R, Juntti N, Rockborn G (1985) An avian influenza A virus killing a mammalian species—the mink. Arch Virol 86: 347–351

    Google Scholar 

  9. Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning, a laboratory manual. Cold Spring Harbor Laboratory Press, New York

    Google Scholar 

  10. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463–5467

    Google Scholar 

  11. Scholtissek C, Bürger H, Kistner O, Shortridge K (1985) The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses. Virology 147: 287–294

    Google Scholar 

  12. Snyder MH, Buckler-White AJ, London WT, Tierney EL, Murphy BR (1987) The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/pintail/79 reassortant viruses for monkeys. J Virol 61: 2857–2863

    Google Scholar 

  13. Steuler H, Schröder B, Bürger H, Scholtissek C (1985) Sequence of the nucleoprotein gene of influenza A/parrot/Ulster/73. Virus Res 3: 35–40

    Google Scholar 

  14. Tomley FM, Roditi IJ (1984) Nucleotide sequence of RNA segment 5, encoding the nucleoprotein of influenza A/FPV/Rostock/34. Virus Res 1: 625–630

    Google Scholar 

  15. Van Rumpuy L, Min Jou W, Huylebroeck D, Devos R, Fiers W (1982) Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (H0N1). Eur J Biochem 116: 645

    Google Scholar 

  16. Von Hoyningen-Huene V, Scholtissek C (1983) Low genetic mixing between avian influenza viruses of different geographic regions. Arch Virol 76: 63–67

    Google Scholar 

  17. Winter G, Fields S (1981) The structure of the gene encoding the nucleoprotein of human influenza virus A/PR/8/34. Virology 114: 423–428

    Google Scholar 

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Authors and Affiliations

  1. Institut für Virologie, Justus-Liebig-Universität Giessen, Giessen, Federal Republic of Germany

    U. Reinhardt & C. Scholtissek

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  1. U. Reinhardt
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  2. C. Scholtissek
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Reinhardt, U., Scholtissek, C. Comparison of the nucleoprotein genes of a chicken and a mink influenza A H 10 virus. Archives of Virology 103, 139–145 (1988). https://doi.org/10.1007/BF01319816

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  • DOI: https://doi.org/10.1007/BF01319816

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