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Antigenic purity and plaque properties of the prototype strains of ECHO virus types 7 to 11, and 17 and 18

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Summary

The properties of plaques produced by ECHO 7, 8, 11, 17, and 18 prototype viruses are described. Rabbit antisera prepared against virus stocks obtained after 2 plaque purification steps (ECHO 7, 8, 11, 17) or 2 terminal dilution passages (ECHO 9, 10) and monkey serum prepared against ECHO 18 virus after 2 terminal dilution passages showed equal neutralization titers vs. original and purified virus of the same type, thus indicating the antigenic purity of the original prototype strains. ECHO reference monkey sera of the corresponding type also showed equal neutralization of the purified and original prototype strains.

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Author notes

  1. Reinhard Wigand

    Present address: Institut für Hygiene und Mikrobiologie der Universität des Saarlandes, Homburg/Saar, Germany

Authors and Affiliations

  1. Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio

    Reinhard Wigand & Albert B. Sabin

Authors
  1. Reinhard Wigand
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  2. Albert B. Sabin
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Additional information

The work reported here was carried out in 1957/58 during Dr.Wigand's tenure of a fellowship in the Cincinnati laboratory. It was aided by grants from The National Foundation.

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Wigand, R., Sabin, A.B. Antigenic purity and plaque properties of the prototype strains of ECHO virus types 7 to 11, and 17 and 18. Archiv f Virusforschung 11, 708–717 (1962). https://doi.org/10.1007/BF01243309

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  • DOI: https://doi.org/10.1007/BF01243309

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