Abstract
Human papillomaviruses (HPV), and human cytomegalovirus (HCMV) have been associated with cervical carcinogenesis. To our knowledge, there has been no report on the role of HCMV in the clinical behavior of cervical cancer. We recently reported that the presence of HPV DNA correlated with a higher incidence of lymph node metastasis, and we now report on whether or not HCMV DNA was present in those 433 cervical carcinomas; 113 cases (26.3%) were confirmed to contain HCMV DNA. HCMV+/HPV+ patients but not HCMV−/HPV+ patients had a significantly higher rate of metastasis to the lymph nodes, compared to HCMV−/HPV− cases (27/92, 29.3% compared to 8/70, 11.4%,P<0.025). Interestingly, the synergistic effects of HCMV and HPV only existed in cervical carcinomas with HPV type 16, and not in those with other HPV genotypes. Only in HPV16+ cases did the presence of HCMV in tumors enhance lymph node metastasis (17/48 compared to 30/152,P<0.05). The results underline the prognostic significance of HCMV in HPV16+ cervical cancer.
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Chen, TM., Chang, CF., Chen, YH. et al. Coexistence of human cytomegalovirus and human papillomavirus type 16 correlates with lymph node metastasis in cervical cancer. J Cancer Res Clin Oncol 122, 629–632 (1996). https://doi.org/10.1007/BF01221196
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DOI: https://doi.org/10.1007/BF01221196