Summary
Double tumors were found in the anterior and posterior lobes of pituitary gland at autopsy in a patient who presented with progressive deterioration of mental status. The chromophobe adenoma of anterior lobe consisted of a mixture of non-immunoreactive hormone containing cells and a few prolactin (PRL) and growth hormone (GH) cells in the mid portion whereas the periphery of the tumor contained immunoreactive cells for PRL, GH, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). A microscopic focus of granular cell myoblastoma (GCM) was found in the posterior lobe. Differentiation of tumor cells into anterior pituitary cells and GCM is discussed.
This is a preview of subscription content, log in via an institution to check access.
References
Abrikossoff AI (1926) Über Myome, ausgehend von der quergestreiften willkürlichen Muskulatur. Virchows Arch Pathol Anat 260:215–233
Avrameas S, Ternynck T (1971) Peroxidase-labelled antibody and Fab conjugates with enhanced intracellular penetration. Immunochemistry 8:1175–1199
Baker BL (1974) Functional cytology of the hypophyseal pars distalis and pars intermedia. In: Knobile E, Sawyer WH, (eds) Handbook of physiology, vol 4, part 1. Amer Physiol Soc, Washington, DC, pp 45–80
Bayliss PH (1976) Case of hyperthyroidism due to a chromophobe adenoma. Clin Endocrinol 5:145–150
Doron Y, Behar A, Beller AJ (1965) Granular-cell myoblastoma of the neurohypophysis. J Neurosurg 22:95–99
Eipper BA, Mains RE (1980) Structure and biosynthesis of proadrenocorticotropin-endorphin and related peptides. Endocrinol Rev 1:1–27
Ezrin C, Kovacs K, Horvath E (1978) Hyperprolactinemia. Med Clin N Am 62:393–408
Fisher ER, Wechser H (1962) Granular cell myoblastoma — a misnomer. Cancer 15:936–954
Hamperl H (1936) Über das Vorkommen von Onkocyten in verschiedenen Organen und ihren Geschwülsten, Virchows Arch Pathol Anat 298:327–375
Horn KE, Erhardt F, Fahlbusch R (1976) Recurrent goiter, hyperthyroidism, galactorrhea, and amenorrhea due to a thyrotropin and prolactin-producing pituitary tumor. J Clin Endocrinol Metab 83:137–143
Ishii T, Iri H, Tamamoto S (1977) Granular cell myoblastoma of the gallbladder. Am J Gastroenterol 68:38–44
Kanabe S, Watanabe I, Lotuaco L (1978) Multiple granular cell tumors of the ascending colon. Dis Colon Rectum 21:322–328
Kohler PO, Bridson WE, Rayford PL (1969) Hormone production by human pituitary adenoma in culture. Metabolism 18:82–788
Kovacs K, Corenblum B, Sivek AMT (1976) Localization of prolactin in chromophobe pituitary adenomas. J Clin Pathol 29:250–258
Lips CJM, van Der Slus Veer J, van Der Donk JA (1978) Common precursor molecule as origin for ectopic-hormone-producing syndrome. Lancet 1:16–18
Marhiter K, Van Noorden S, Marco L (1979) Hormone secretion by human somatotrophic lactotropic, and mixed pituitary adenoma in culture. J Clin Endocrinol Metab 48:105–113
McCormick WF, Halmi NS (1971) Absence of chromophobe adenomas from a large series of pituitary tumors. Arch Pathol 92:231–238
Muller W, Klein PS, Newman RA (1980) Histochemical methods for the burder characterization of the tumorettes of the posterior lobe of the pituitary. Acta Neuropathol 49:101–103
Murray MD (1951) Cultural characteristics of three granular cell myoblastomas. Cancer 4:857–865
Nakane PK (1976) Classification of anterior pituitary cells with immunoenzyme histochemistry. J Histochem Cytochem 18:9–20
Ontjes DA, Ney RL (1976) Pituitary tumors. CA 26:330–350
Pearse AGE (1950) The histogenesis of granular cell myoblastoma. J Pathol Bact 62:351–362
Pearse AGE (1977) The diffuse neuroendocrine system and APUD concept. Med Biol 55:115–125
Rubinstein LJ (1972) Choristoma of the neurohypophysis. In: Tumors of the central nervous system. Armed Forces Institute of Pathology, Washington, DC, pp 299–300
Satyamurti S, Huntington HW (1972) Granular cell myoblastoma of the pituitary. J Neurosurg 37:483–486
Scanarini M, Mingrino S (1979) Pituitary adenomas secreting more than two hormones. Acta Neuropathol (Berl) 48:67–72
Sobel NJ, Schwartz R, Marquet E (1973) Light- and electronmicroscopic study of the origin of granular cell myoblastoma. J Pathol 109:101–111
Taylor CR (1978) Immunoperoxidose techniques. Arch Pathol Lab Med 102:113–121
Tolis G, Somma M, Van Campenhout J (1974) Prolactin secretion in sixtyfive patients with galactorrhea. Am J Obstet Gynecol 118:91–101
Tomita T, Bhatia P, Gourley W (1981) Mucin-producing islet cell adenoma. Human Pathol (in press)
Ulrich J, Landolt A, Benini A (1974) Granularer Zelltumor im 3. Ventrikel des Großhirns. Acta Neuropathol (Berl) 27:215–223
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tomita, T., Kuziez, M. & Watanabe, I. Double tumors of anterior and posterior pituitary gland. Acta Neuropathol 54, 161–164 (1981). https://doi.org/10.1007/BF00689411
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00689411