Skip to main content
SpringerLink
Log in

Cortisone cataract in children with nephrotic syndrome

  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

In a group of 16 children with idiopathic nephrotic syndrome treated with corticosteroids for longer than 12 months, 9 developed a posterior subcapsular cataract (PSC). No correlation between the frequency of PSC and the duration of treatment and the total dose of treatment with steroids was demonstrable. However, the patients with PSC had received considerably higher average daily doses than those without PSC. Two patients with normal ophthalmologic findings at the end of treatment showed PSC 6 and 9 months later respectively. Only one patient acquired a signficant impairement of visus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Black, R. L. et al.: Posterior subcapsular cataracts induced by corticosteroids in patients with rheumatoid arthritis. J. Amer. Med. Ass. 174, 166–171 (1960)

    Google Scholar 

  2. Abrahamson, J. A., Jr., Abrahamson, J. A., Sr.: Cataracta complicata and corticosteroids. Eye Ear Nose Throat Monthly 40, 266–268 (1961)

    Google Scholar 

  3. Gordon, D. M. et al.: Examination for posterior subcapsular cataracts. J. Amer. Med. Ass. 175, 127–129 (1961)

    Google Scholar 

  4. Hart, F. D. et al.: Cataract and steroids. Brit. Med. J. 1961I, 1680–1681

  5. Oglesby, R. B., et al.: Cataracts in rheumatoid arthritis patients treated with corticosteroids. Arch. Ophthal. 66, 519–523 (1961)

    Google Scholar 

  6. Oglesby R. B., et al.: Cataracts in patients with rheumatic diseases treated with corticosteroids. Arch. Ophthal. 66, 625–630 (1961)

    Google Scholar 

  7. Pfahl, S. B., et al.: Relationship of steroid therapy and cataracts in patients with rheumatoid arthritis. Amer. J. Opth. 52, 831–834 (1961)

    Google Scholar 

  8. Toogood, J. H. et al.: Posterior subcapsular cataracts as a complication of adrenocortical steroid therapy. Canad. Med. Ass. J. 86, 52–56 (1962)

    Google Scholar 

  9. Giles, C. L., et al.: The association of cataract formation and systemic corticosteroid therapy. J. Amer. Med. Ass. 182, 719–722 (1962)

    Google Scholar 

  10. Crews, S. J.: Posterior subcapsular lens opacities in patients on long-term corticosteroid therapy. Brit. Med. J. 1963I, 1644–1647

  11. Leibold, J. E., Itkin, J. H.: Cataracts in asthmatics treated with corticosteroids. J. Amer. Med. Ass. 185, 448 (1963)

    Google Scholar 

  12. Sundmark, E.: The occurence of posterior subcapsular cataracts in patients on long-term systemic corticosteroid therapy. Acta Ophthalmol 41, 515–523 (1963)

    Google Scholar 

  13. Hofmann, W. B., Hauser, P. J.: Disseminated lupus erythematosus. Amer. J. Ophth. 57, 1043–1045 (1964)

    Google Scholar 

  14. Crews, S. J.: Adverse reactions to corticosteroid therapy in the eye. Proc. Roy. Soc. Med. 58, 533–535 (1965)

    Google Scholar 

  15. Frandsen, E.: Spontaneous absorption of cortisone induced cataract. Acta Ophthalmol. 43, 605–609 (1965)

    Google Scholar 

  16. Havre, D. C.: Cataracts in children on long-term corticosteroid therapy. Arch. Ophthal. 73, 818–821 (1965)

    Google Scholar 

  17. Ley, A. P. et al.: Corticosteroid therapy and subcapsular cataracts. J. Amer. Med. Ass. 191, 753 (1965)

    Google Scholar 

  18. Braver, D. A. et al.: Posterior subcapsular cataracts in corticosteroid-treated children. J. Pediat. 69, 735–738 (1966)

    Google Scholar 

  19. Fürst, C. et al.: Steroid cataract. Ann. Rheum. Dis. 25, 364–368 (1966)

    Google Scholar 

  20. Spaeth, G. L., von Sallmann, L.: Corticosteroids and cataracts. Intern. Ophthal. Clinics 6, 915–928 (1966)

    Google Scholar 

  21. Knoke, M., Benthien, H.: Die Steroid-Katarakt. Zschr. inn. Med. 22, 500–502 (1967)

    Google Scholar 

  22. Leopold, J. H., Barnert, A. H.: Steroids in ophthalmology. Adv. Ophthal. 18, 21–22 (1967)

    Google Scholar 

  23. Schwenk, D.: Linsenveränderungen bei rheumatischen Kindern bei langfristiger Corticosteroidtherapie. Zschr. f. Rheumaforschung 26, 153–165 (1967)

    Google Scholar 

  24. Wood, D. C. et al.: Response of rabbits to corticosteroids. I. Influence on growth, intraocular pressure and lens transparency. Amer. J. Ophth. 63, 841–849 (1967)

    Google Scholar 

  25. Bettmann, J. W. et al.: Cataractogenic effect of corticosteroids on animals. Amer. J. Ophth. 65, 581–586 (1968)

    Google Scholar 

  26. Bihari, M., Grossman, B. J.: Posterior subcapsular cataracts. Amer. J. Dis. Child. 116, 604–608 (1968)

    Google Scholar 

  27. Borgmann, H.: Linsentrübungen nach „kurzzeitiger” Cortisonbehandlung. Klin. Mbl. Augenhk. 153, 542–547 (1968)

    Google Scholar 

  28. Cremer-Bartels, G. et al.: Additionscatarakt nach Corticosteroidapplikation bei Galaktose-gefütterten Ratten. Ber. dtsch. Ophth. Ges. 69, 436–440 (1968)

    Google Scholar 

  29. Giles, C. L. et al.: Cataract formation and systemic corticosteroid therapy in nephrotic children. J. Pediat. Ophthal. 6, 77–80 (1969)

    Google Scholar 

  30. Williamson, J. et al.: Posterior subcapsular cataracts and glaucoma associated with longterm oral corticosteroid therapy. Brit. J. Ophthal. 53, 361–372 (1969)

    Google Scholar 

  31. Rintelen, F., Dobrivojevic, D.: Über Cortison-Katarakt bei Nierentransplantation. Ophthalmologica (Basel) 161, 125–131 (1970)

    Google Scholar 

  32. Bethge, H.: Alternierende Corticoidtherapie. Dtsch. Med. Wschr. 96, 1254–1259 (1971)

    Google Scholar 

  33. Paterson, C. A.: Effects of drugs on the lens. In: Side effects of drugs in ophthalmology. Intern. Ophthal. Clinics 11, 71–76 (1971)

    Google Scholar 

  34. Hall, G. H., Proctor, E. A.: Cataracts after renal transplantation. Brit. Med. J. 1972I, 469

  35. Leroux-Robert, C. et al.: Ocular complications in renal transplantation. Brit. Med. 1972I, 586

  36. Loredo, A. et al.: Cataracts after short-term corticosteroid treatment. N. Engl. J. Med. 286, 160 (1972)

    Google Scholar 

  37. Mahlich, J. et al.: Die Cortisonkatarakt nach Nierentransplantation. Dtsch. Med. Wschr. 97, 860–865 (1972)

    Google Scholar 

  38. Millet, V. G. et al.: Cataracts after renal transplantation. Brit. Med. J. 1972II, 47

  39. Ono, S. et al.: Presence of cortisol-binding protein in the lens. Ophthal. Res. 3, 233–240 (32972)

    Google Scholar 

  40. Porter, R. et al.: Incidence of ocular complications in patients undergoing renal transplantation. Brit. Med. 1972I, 136

  41. Porter, R., Crombie, A.: Cataracts after renal transplantation. Brit. Med. J. 1972 I, 766

  42. Friedburg, D.: Der kataraktinduzierende Effekt der Glucokorticoide. In: Kortikosteroide in der Augenheilkunde, Symposion der Deutschen Ophthalmologischen Gesellschaft vom 28.–30. Sept. 1972 in Kiel. München: J. F. Bergmann 1973

    Google Scholar 

  43. Kobayashi, Y. et al.: Posterior subcapsular cataract in nephrotic children receiving steroid therapy. Amer. J. Dis. Child. 128, 671–673 (1974)

    Google Scholar 

  44. Loreto, J. A. et al.: Steroid-associated cataracts in nephrotic syndrome: A preliminary report. J. Pediat. Ophthal. 11, 112–115 (1974)

    Google Scholar 

  45. Hübner, F. K.: Katarakte als Nebenwirkung der Cortisonlangzeitbehandlung von Lipoidnephrosen bei Kindern. Pädiat. Prax. 16, 505–506 (1976)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätskinderklinik, Hufelandstr. 15, D-4300, Essen 1, Germany

    H. J. Bachmann, P. Schildberg, H. Olbing, D. Krämer & Th. Waubke

  2. Universitätsaugenklinik (Abteilung für Ophthalmologische Mikrochriurgie und Traumatologie), Hufelandstr. 55, D-4300, Essen 1, Germany

    H. J. Bachmann, P. Schildberg, H. Olbing, D. Krämer & Th. Waubke

Authors
  1. H. J. Bachmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Schildberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Olbing
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Krämer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Th. Waubke
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bachmann, H.J., Schildberg, P., Olbing, H. et al. Cortisone cataract in children with nephrotic syndrome. Eur J Pediatr 124, 277–283 (1977). https://doi.org/10.1007/BF00441935

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00441935

Key words

Search

Navigation