Abstract
An Arab Moslem kindred is reported in which six abnormal male fetuses were born in three closely related sibships. They had amelia, malformed head and other severe skeletal and visceral malformations. The similarities and differences between the developmental and inherent characteristics found in our patients and in families with Roberts syndrome are discussed.
Similar content being viewed by others
References
Dresher CS, MacDonell JA (1965) Total amelia. J Bone Joint Surg [Am] 47:511–516
Freeman MVR, Williams DW, Schimke RN, Temtamy SA, Vachier F, German J (1974) The Roberts syndrome. Clin Genet 5:1–16
German J (1979) Roberts syndrome. I. Cytological evidence for a disturbance in chromatid pairing. Clin Genet 16:441–447
Grosse FR, Pandel C, Wiedemann HR (1975) The tetraphocomelia—cleft palate syndrome. Humangenetik 28:353–356
Herrmann J, Opitz JM (1977) The SC phocomelia and the Roberts syndrome: Nosologic aspects. Eur J Pediatr 125:117–134
Mann NP, Fitzsimmons J, Fitzsimmons E, Cooke P (1982) Roberts syndrome: clinical and cytogenetic aspects. J Med Genet 19:116–119
Potter EL, Craig JM (1976) Tetra-amelia. In: Pathology of the fetus and infant. Year Book Medical Publisher, Chicago, p 598
Willner JP, Radu M, Hobbins JC, Kerenyi T, Strauss L, Desnick RJ (1979) Roberts syndrome. Pediatr Res 13:428
Zergollern L, Hitrec V (1976) Three siblings with Roberts syndrome. Clin Genet 9:433–436
Zergollern L, Hitrec V (1982) Four siblings with Roberts syndrome. Clin Genet 21:1–6
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zimmer, E.Z., Taub, E., Sova, Y. et al. Tetra-amelia with multiple malformations in six male fetuses of one kindred. Eur J Pediatr 144, 412–414 (1985). https://doi.org/10.1007/BF00441792
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00441792