Skip to main content
Log in

Tetra-amelia with multiple malformations in six male fetuses of one kindred

  • Case Reports
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

An Arab Moslem kindred is reported in which six abnormal male fetuses were born in three closely related sibships. They had amelia, malformed head and other severe skeletal and visceral malformations. The similarities and differences between the developmental and inherent characteristics found in our patients and in families with Roberts syndrome are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Dresher CS, MacDonell JA (1965) Total amelia. J Bone Joint Surg [Am] 47:511–516

    Google Scholar 

  2. Freeman MVR, Williams DW, Schimke RN, Temtamy SA, Vachier F, German J (1974) The Roberts syndrome. Clin Genet 5:1–16

    Google Scholar 

  3. German J (1979) Roberts syndrome. I. Cytological evidence for a disturbance in chromatid pairing. Clin Genet 16:441–447

    Google Scholar 

  4. Grosse FR, Pandel C, Wiedemann HR (1975) The tetraphocomelia—cleft palate syndrome. Humangenetik 28:353–356

    Google Scholar 

  5. Herrmann J, Opitz JM (1977) The SC phocomelia and the Roberts syndrome: Nosologic aspects. Eur J Pediatr 125:117–134

    Google Scholar 

  6. Mann NP, Fitzsimmons J, Fitzsimmons E, Cooke P (1982) Roberts syndrome: clinical and cytogenetic aspects. J Med Genet 19:116–119

    Google Scholar 

  7. Potter EL, Craig JM (1976) Tetra-amelia. In: Pathology of the fetus and infant. Year Book Medical Publisher, Chicago, p 598

    Google Scholar 

  8. Willner JP, Radu M, Hobbins JC, Kerenyi T, Strauss L, Desnick RJ (1979) Roberts syndrome. Pediatr Res 13:428

    Google Scholar 

  9. Zergollern L, Hitrec V (1976) Three siblings with Roberts syndrome. Clin Genet 9:433–436

    Google Scholar 

  10. Zergollern L, Hitrec V (1982) Four siblings with Roberts syndrome. Clin Genet 21:1–6

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zimmer, E.Z., Taub, E., Sova, Y. et al. Tetra-amelia with multiple malformations in six male fetuses of one kindred. Eur J Pediatr 144, 412–414 (1985). https://doi.org/10.1007/BF00441792

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00441792

Key words

Navigation