Summary
Muscle biopsies were studied from sixteen juvenile, long-term diabetics. Most of the patients had severe retinopathy, but clinical signs of other forms of angiopathy and neuropathy were either absent or mild. The biopsies revealed severe degeneration, as well as ineffective regenerative changes of the terminal nerve fibres and endorgans.
Résumé
Des biopsies musculaires ont été étudiées chez seize sujets jeunes diabétiques depuis longtemps. La plupart des patients étaient atteints de rétinopathie grave, mais les signes cliniques d'autres formes d'angio-pathie et de neuropathie étaient soit absents, soit légers. Les biopsies ont révélé une dégénérescence grave ainsi que des modifications régénératives inefficaces des fibres nerveuses terminales et des organes terminaux.
Zusammenfassung
Es wurden Muskelbiopsien von 16 jüngeren Langzeitdiabetikern untersucht. Die meisten Patienten litten an einer schweren Rétinopathie, doch wiesen sie nur schwache oder keine klinischen Anzeichen eines anderen Gefäßleidens oder einer Neuropathie auf. Die Biopsien zeigten schwere degenerative Erscheinungen und außerdem frustrane regenerative Veränderungen der terminalen Nervenfasern und Endorgane.
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Reske-Nielsen, E., Lundbaek, K., Gregersen, G. et al. Pathological changes in the central and peripheral nervous system of young long-term diabetics. Diabetologia 6, 98–103 (1970). https://doi.org/10.1007/BF00421436
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DOI: https://doi.org/10.1007/BF00421436