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Topical treatment of ichthyoses and Darier's disease with 13-cis-retinoic acid

A clinical and immunohistochemical study

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Abstract

In a bilaterally paired double-blind comparison study, a cream containing 0.1% 13-cis-retinoic acid (13-cis-RA) and cream base only were applied over 4 weeks in seven patients with non-erythrodermic lamellar ichthyosis (NELI), two patients with Darier's disease and one patient with autosomal dominant ichthyosis vulgaris (ADIV). In two patients with NELI and two patients with Darier's disease a half-side effect was observed in favour of the side treated with 13-cis-RA. In three patients an induction of cytokeratin-4, and in one of these patients expression of cytokeratin-13, were observed after therapy. Topical 13-cis-RA-appears to be a promising approach in the treatment of disorders of keratinization. The selective modulation of the cytokeratin pattern may provide an immunohistochemical tool to investigate the mode of action of retinoids.

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Authors and Affiliations

  1. Department of Dermatology, University Hospital Nijmegen, PO Box 9101, NL-6500, HB Nijmegen, The Netherlands

    P. M. Steijlen, D. O. H. Reifenschweiler, R. Happle & P. C. M. van de Kerkhof

  2. Department of Pathology, University Hospital Nijmegen, Nijmegen, The Netherlands

    G. N. P. van Muijen & D. J. Ruiter

  3. Department of Molecular Cell Biology, University of Limburg, Maastricht, The Netherlands

    F. C. S. Ramaekers

Authors
  1. P. M. Steijlen
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  2. D. O. H. Reifenschweiler
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  3. F. C. S. Ramaekers
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  4. G. N. P. van Muijen
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  5. R. Happle
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  6. M. Link
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  7. D. J. Ruiter
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  8. P. C. M. van de Kerkhof
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Steijlen, P.M., Reifenschweiler, D.O.H., Ramaekers, F.C.S. et al. Topical treatment of ichthyoses and Darier's disease with 13-cis-retinoic acid. Arch Dermatol Res 285, 221–226 (1993). https://doi.org/10.1007/BF00372013

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  • DOI: https://doi.org/10.1007/BF00372013

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