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Primary central white matter degeneration in old dogs

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Summary

Degeneration of the central white matter is described in old dogs. The presence of ubiquitin-immunoreactive free granules and intracytoplasmic globules in glial cells and macrophages, together with galactocerebroside-immunoreactive precipitates and lipofuscin storage, point to the likelihood of a primary myelin degeneration with deposits of non-degraded ubiquitin-protein conjugates and complex galactolipids.

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Authors and Affiliations

  1. Unit of Neuropathology, Service of Pathology, Hospital Principes de España, University of Barcelona, E-08907, Hospitalet de Llobregat, Spain

    I. Ferrer, R. Rivera, M. J. Zújar & A. Vidal

  2. Neurological Tissue Bank, Faculty of Medicine, Autonomous University of Barcelona, Bellaterra, Spain

    F. Cruz-Sánchez

  3. Pathology Department, Veterinary School, Autonomous University of Barcelona, Bellaterra, Spain

    M. Pumarola

Authors
  1. I. Ferrer
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  2. M. Pumarola
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  3. R. Rivera
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  4. M. J. Zújar
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  5. F. Cruz-Sánchez
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  6. A. Vidal
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Supported in part by a grant FIS 93-131

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Ferrer, I., Pumarola, M., Rivera, R. et al. Primary central white matter degeneration in old dogs. Acta Neuropathol 86, 172–175 (1993). https://doi.org/10.1007/BF00334884

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  • DOI: https://doi.org/10.1007/BF00334884

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