Summary
The disease of a four week old boy is described, which presented with papulous skin infiltrations, lethargy, anemia and bilateral testicular swelling. The investigation of bone marrow, cerebrospinal fluid and skin biopsy revealed infiltration by a leukemic process which could be identified by means of cytology and cytochemistry as erythroleukemia at the stage of erythremic myelosis. Death occurred 20 days after the onset of symptoms. Only one previous report of congenital erythroleukemia could be found in the literature. The findings are briefly discussed.
Similar content being viewed by others
References
Bjure J, Fichtelius K-E, Ranström S (1960) On the problem of congenital hemopathies (congenital myeloid and erythremic blood picture). Acta Paediatr Scand 49: 358–370
Brescia MA, Santora E, Sarnataro VF (1959) Congenital leukemia. J Pediatr 55: 35–41
Bühler M, Landoldt R (1970) Kongenitale Leukämie. Helv Pediatr Acta 25: 176–193
Dameshek W (1969) The DiGulielmo syndrome revisited. Blood 34: 567–572
Diekmann L, Rickers H, Pfeiffer RA, Bäumer A (1969) Morphologische, immunzytologische und zytogenetische Untersuchungen bei einem Kind mit Erythroleukämie. Blut 18: 321–333
Drescher J, Hansen HG, Althoff H, Graucob E (1969) Das Di-Guglielmo-Syndrom im Kindesalter. Dtsch Med Wochenschr 94:2415–2421
Haahr J, Halveg AB (1971) Congenital leukemia. Acta Paediatr Scand 60: 720–723
Huhn D, Kaboth W, Schmalzl F (1973) Di-Guglielmo-Syndrom. Klinische, zytochemische, elektronenmikroskopische Befunde. Dtsch Med Wochenschr 98: 355–360
Mödder B, Blümke S, Havers W, Sehlhorst D, Haupt H (1975) Angeborene Leukose mit ungewöhnlichem Hirnbefall. Klin Pädiatr 187: 101–107
Morse H, Hays T, Peakman D, Rose B, Robinson A (1979) Acute nonlymphoblastic leukemia in childhood. Cancer 44: 164–170
Pierce M (1959) Leukemia in the newborn infant. J Pediatr 54: 691–706
Prematilleke MN, Balasubramaniam CC (1968) Erythroleukemia in an infant. Ceylon Med J 13: 41–46
Roloff JS, Najjar JL, Lukens JN (1978) Erythroleukemia in an infant with neurofibromatosis. J Pediatr 93: 888–889
Wegelius R, Peltonen T (1954) Erythremic myelosis (di Guglielmo) in an infant. Acta Paediatr Scand 43: 280–288
Wolk R, Stuart MJ, Davey FR, Nelson DA (1974) Congenital and neonatal leukemia-lymphocytic or myelocytic? Am J Dis Child 128: 864–866
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lasson, U., Goos, M. Congenital erythroleukemia. Blut 43, 237–241 (1981). https://doi.org/10.1007/BF00320452
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00320452