Abstract
Metastatic lesions from renal cell carcinoma are commonly recognized in the lung and bone, however, thyroid metastasis has rarely been reported in the literature. We present herein a case of a man with lung and thyroid metastatic tumors from renal cell carcinoma. Although making a preoperative diagnosis of thyroid metastasis is difficult because there is no established diagnostic criteria, we were able to identify this thyroid lesion as a metastatic tumor from renal cell carcinoma by the pathological findings. Interestingly, hypercalcemia was recognized in this patient whose serum parathyroid hormone (PTH) level was not increased. Moreover, this patient also had early gastric cancer simultaneously, being a so-called ‘double cancer’. After surgical resection of the right kidney and stomach, interferon was administered without any efficacy against the metastatic lesions of the lung and thyroid gland.
References
Kobayashi K, Yashiro T, Suzuki A, Manabe Y, Ozaki O, Ito K (1988) Two cases of metastatic tumor to the thyroid gland. (in Japanese) J Jpn Soc Clin Surg 49:814–819
Shimaoka K, Sokal JE, Pickren JW (1962) Metastatic neoplasms in the thyroid gland. Cancer 15:557–565
Freund HR (1965) Surgical treatment of metastases to the thyroid gland from other primary malignancies. Ann Surg 162:285–290
Elliott RHE, Frantz VK (1960) Metastatic carcinoma masquerading as primary thyroid cancer. Ann Surg 151:551–561
Mortensen JD, Woolner LB, Bennett WA (1956) Secondary malignant tumors of the thyroid gland. Cancer 9:306–309.
Wychulis AR, Beahrs OH, Woolner LB (1964) Metastasis of carcinoma to the thyroid gland. Ann Surg 160:169–177.
Kitamura M, Hosomi M, Namiki M, Nakano E, Sonoda T (1988) A case of solitary metastasis of renal cell carcinoma to the thyroid gland. (in Japanese) Acta Urol Jpn 34:147–150.
Kato A, Miyahara Y, Yanohara K, Yabana T, Hosina A, Nagano M (1989) Renal cell carcinoma metastasized to the thyroid: Report of a case. (in Japanese) Otolaryngol Head Neck Surg 61:1025–1028
Linton RR, Barney JD, Moorman HD, Lerman J (1946) Metastatic hypernephroma of the thyroid gland. Surg Gynecol Obstet 83:493–498
Dempsey WS, Crile GJ, Engel WJ (1952) Clear cell carcinoma (hypernephroma) of the kidney with metastasis to the thyroid gland. J Urol 68:576–578
Oomi Y, Hata M, Ohta N, Suzuki K, Tajima A, Fujita K, Aso Y (1982) A case of regression of pulmonary and fibular metastases arising from renal cell carcinoma following nephrectomy. Acta Urol Jpn 28:731–736
Ohno R (1987) Clinical studies of interferon on cancer in Japan. (in Japanese) Jpn J Cancer Chemother 14:1194–1202
Nishio Y, Yoshida O (1988) Recent management of renal cell carcinoma. (in Japanese) Jpn J Cancer Chemother 15:219–223
Mundy GR, Ibbotson K, D'Souza SM, Simpson EL, Jacobs JW, Martin TJ (1984) The hypercalcemia of cancer. N Eng J Med 310:1718–1727
Powell DD, Singer FR, Murray TM, Minkin C, Potts JT (1973) Nonparathyroidal humoral hypercalcemia in patients with neoplastic diseases. N Eng J Med 289:176–181
Greenberg PB, Martin TJ, Sutcliffe HS (1973) Synthesis and release of parathyroid hormone by a renal carcinoma in cell culture. Clin Sci Mol Med 45:183–191
Goldgerg MF, Tashjian AH, Order SE, Dammin GJ (1964) Renal adenocarcinoma containing a parathyroid hormone-like substance and associated with marked hypercalcemia. Am J Med 36:805–814
Mundy GR, Ibbotson KJ, D'Souza SM (1985) Tumor products and hypercalcemia of malignancy. J Clin Invest 76:391–394
Nakano S, Suzuki S, Kinbara H, Maeda Y, Yanagawa M, Tajima K, Tochigi H, Kawamura J (1990) A case of double cancer: Renal cell carcinoma and transitional cell carcinoma of urinary bladder. (in Japanese) Acta Urol Jpn 36:831–835
Funaki H, Suzuki N, Adachi M, Sakakibara T, Sakuma Y, Ohhori T (1985) Double primary malignant neoplasm of renal cell carcinoma and stomach cancer: Report of two cases. (in Japanese) Acta Urol Jpn 9:1629–1634
Haba Y, Masuda H, Sugenoya A, Senga O, Kobayashi S, Iida F, Kato M. (1990) A case of quadruple cancer composed of the breast, kidney, liver, and uterus carcinomas. (in Japanese) J Jpn Surg Soc 91:649–651
Ray PR, Sharifi R, Ortolano V, Guinan P (1983) Involvement of the genitourinary system in multiple primary malignant neoplasms. J Clin Oncol 1:574–581
Masuda F, Suzuki H, Kondo I, Furuta N, Asano K, Makino H (1990) Double cancer including renal cell carcinoma. (in Japanese) Jpn J Clin Urol 44:493–495
Honda M, Oda M, Nakamura T, Nakamura S, Ichikawa S, Onishi S (1989) A case of resected triple cancer (renal, colon, and gastric cancer). (in Japanese) Jpn J Urol Surg 2:1139–1142
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Murakami, S., Yashuda, S., Nakamura, T. et al. A case of renal cell carcinoma with metastasis to the thyroid gland and concomitant early gastric cancer. Surg Today 23, 153–158 (1993). https://doi.org/10.1007/BF00311234
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00311234