Abstract
A group of 45 male alcoholics were studied during acute withdrawal. Patients were kept in hospital and treated with amobarbital (15 patients), oxazepam (15 patients), and melperone (15 patients) respectively in a double-blind design. Clinical symptoms were rated with a modified version of the Comprehensive Psychopathological Rating Scale after 1, 4 and 7 days. Blood pressure, body temperature and pulse rate were also recorded. Lumbar cerebrospinal fluid was collected after 1 and 7 days. A group of healthy males served as controls. The three treatment groups showed only small differences with regard to the investigated clinical items, except for a higher incidence of epileptic fits being evidenced in the melperone group. Levels of HVA in the cerebrospinal fluid did not differ between the treatment groups and the controls and did not change during treatment. Statistically significant correlations were noted between levels of HVA and auditory and visual hallucinations as well as concentration difficulties. Assuming that HVA levels reflect the activity of the central nervous dopamine system, the findings indicate a connection between central dopamine metabolism, psychotic symptoms and possibly other symptoms during acute alcohol withdrawal in man.
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Annunziato L, Amorosa S, Di Renzo G, Argarzio F, Auzi C, Grella A, Quattrone A (1983) Increased GH responsiveness to dopamine receptor stimulation in alcohol addicts during the late withdrawal syndromes. Life Sci 33:2651–2655
Ballenger I, Goodwin FK, Major L, Brown GL (1979) Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry 36:224–227
Bjerkenstedt L, Gullberg B, Härnryd C, Sedvall G (1977) Monoamine metabolite levels in cerebrospinal fluid of psychotic women treated with melperone or thiothixene. Arch Psychiatr Nervenkr 224:107–118
Borg V, Weinholdt T (1982) Bromocriptine in the treatment of the alcohol-withdrawal syndrome. Acta Psychiatr Scand 65:101–111
Borg S, Czarnecka A, Kvande H, Mossberg D, Sedvall G (1983) Clinical conditions and concentrations of MOPEG in the cerebrospinal fluid and urine of alcoholic patients during withdrawal. Alcohol Clin Exp Res 7:4, 411–415
Carlsson A, Adolfsson R, Aquilonius SM, Gottfries CG, Oreland L, Svennerholm L, Winblad B (1979) Biogenic amines in human brain in normal aging, senile dementia and chronic alcoholism. Presented at the International Symposium on Ergot Alkaloids in Neurologic, Neuropsychiatric and Endocrine Disorders, New York
Ferguson A (1959) Statistical analysis in psychology and education. McGraw Hill Book Co.
Hoffman PL, Tabakoff B (1977) Alterations in dopamine receptor sensitivity by chronic ethanol treatment. Nature (London) 268:551–553
Kaim SC, Klett CJ, Rothfeld D (1968) Treatment of acute withdrawal state, a comparison of four drugs. Report 2 Central Neuropsychiatric Research Laboratory, Perry Point, Maryland
Kryspin-Exner K, Demel I (1975) The use of tranquilizers in the treatment of mixed drug abuse. Int J Clin Pharmacol 12(1–2):13–18
Lai H, Makous WL, Horita A, Leung H (1979) Effects on ethanol on turnover and function of striatal dopamine. Psychopharmacology 61:1–9
Major LF, Ballenger JC, Goodwin FK, Brown GL (1977) Cerebrospinal fluid homovanillic acid in male alcoholics: Effects of disulfiram. Biol Psychiatry 12:5, 635–642
Orenberg EK, Zarcone VP, Renson JF, Barchas JD (1976) The effects of ethanol ingestion on cyclic AMP, homovanillic acid and 5-hydroxyindoleacetic acid in human cerebrospinal fluid. Life Sci 19:1669–1672
Roos BE, Silfverskiöld BP (1973) Homovanillic acid in cerebrospinal fluid of alcoholics. N Engl Med J 1358–1359
Sedvall G, Fyrö B, Gullberg B, Nybäck H, Wiesel FA, Wode-Helgodt B (1980) Relationship in healthy volunteers between concentrations of monoamine metabolites in cerebrospinal fluid and family history of psychiatric morbidity. Br J Psychiatry 136:366–374
Swahn DG, Sandgärde B, Wiesel FA, Sedvall G (1976) Simultaneous determination of the three major monoamine metabolites in brain tissue and body fluids by a mass fragmentographic method. Psychopharmacology 48:147
Tabakoff B, Hoffman PL (1979) Development of functional dependence on ethanol in dopaminergic systems. Pharmacology 208:2, 216–222
Tabakoff B, Hoffman PL, Ritzmann RF (1978) Dopamine receptor function after chronic ingestion of ethanol. Life Sci 23:643–648
Takahashi S, Yamane H, Kondo H, Tani N, Kato N (1974) CSF monoamine metabolites in alcoholism: A comparative study with depression. Folia Psychiatr Neurol Jpn 28:347–354
Valverius P, Borg S, Hoffman PL, Tabakoff B (1985) Neuroreceptoren im Gehirn Alkoholkranker eine postmortale Vergleichsstudie der dopaminergen und cholinergen Transmittorsysteme. In Keup W: Biologie der Sucht, Springer Verlag pp 99–102
World Health Organization (1974) WHO Tech Rep Ser 551
Åsberg M, Perris C, Schalling D, Sedvall G (1978) The CPRS-development and applications of a psychiatric rating scale. Acta Psychiatr Scand: suppl 271
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Borg, S., Kvande, H. & Valverius, P. Clinical conditions and central dopamine metabolism in alcoholics during acute withdrawal under treatment with different pharmacological agents. Psychopharmacologia 88, 12–17 (1986). https://doi.org/10.1007/BF00310506
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DOI: https://doi.org/10.1007/BF00310506