Article PDF
Avoid common mistakes on your manuscript.
References
Williams JR (1922) A clinical study of the effects of insulin in severe diabetes. J Metab Res 2: 729–751
Joslin EP (1935) The treatment of diabetes mellitus, 5th ed. Henry Kimpton, London, p 294–297
Lowell FC (1944) Immunologie studies in Insulin resistance: II the presence of a neutralizing factor in the blood exhibiting some characteristics of an antibody. J Clin Invest 23: 233–240
Berson SA, Yalow RS, Bauman A, Rothschild MA, Newerly K (1956) Insulin I131 metabolism in human subjects. Demonstration of insulin binding globulin in circulation of insulin treated subjects. J Clin Invest 35: 170–190
Berson SA, Yalow RS (1959) Quantitative aspects of the reaction between insulin and insulin-binding antibody. J Clin Invest 38: 1996–2016
Berson SA, Yalow RS (1957) Studies with insulin-binding antibody. Diabetes 6: 402–405
Berson SA, Yalow RS (1959) Species-specificity of human anti-beef, pork insulin serum. J Clin Invest 38: 2017–2025
Oakley WG, Jones VE, Cunliffe AC (1967) Insulin resistance. Br Med J II: 134–138
Harwood R (1960) Insulin-binding antibodies and “spontaneous” hypoglycaemia. N Engl J Med 262: 978–979
Hirata Y, Tominaga M, Ito JI, Noguchi A (1974) Spontaneous hypoglycaemia with insulin autoimmunity in Graves' disease. Ann Intern Med 81: 214–218
Goldman J, Baldwin D, Rubenstein AH, Klink DD, Blackard WG, Fisher LK, Roe TF, Schnure JJ (1979) Characterization of circulating insulin and proinsulin-binding antibodies in autoimmune hypoglycaemia. J Clin Invest 63: 1050–1059
Schernthaner G, Ludwig H, Mayr WR (1979) Immunoglobulin G-insulin antibodies and immune region-associated alloantigens in insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 48: 403–407
Deckert T, Egeberg J, Frimodt-Moller C, Sander E, Svejgaard A (1979) Basement membrane thickness, insulin antibodies and HLA-antigens in longstanding insulin dependent diabetes with and without severe retinopathy. Diabetologia 17: 91–96
Andersen OO (1976) Clinical significance of anti-insulin antibodies. Acta Endocrinol (Kbh) 83 [Suppl 205]: 231–240
Dixon K, Exon PD, Malins JM (1975) Insulin antibodies and the control of diabetes. J Q Med 44: 543–553
Asplin CM, Hartog M, Goldie DJ (1978) Change of insulin dosage, circulating free and bound insulin and insulin antibodies on transferring diabetes from conventional to highly purified porcine insulin. Diabetologia 14: 99–105
Gonen B, Goldman J, Baldwin D, Goldberg RB, Ryan WG, Blix PM, Schanzlin D, Fritz KJ, Rubenstein AH (1979) Metabolic control in diabetic patients. Effect of insulin-secretory reserve (measured by plasma C-peptide levels) and circulating insulin antibodies. Diabetes 28: 749–753
Yue DK, Baxter RC, Turtle JR (1978) C-peptide secretion and insulin antibodies as determinants of stability in diabetes mellitus. Metabolism 27: 35–44
Bollinger RE, Morris JH, McKnight FG, Diederich DA (1964) Disappearance of 131I labeled insulin from plasma as a guide to management of diabetes. N Engl J Med 270: 767–770
Asplin CM, Hartog M, Goldie DJ, Alberti KGMM, Smythe P, Binder C, Faber O (1978) A comparison between diabetics receiving a high or low daily insulin dosage. Horm Metab Res 10: 365–369
Berson SA, Yalow RS (1966) Insulin in blood and insulin antibodies. Am J Med 40: 676–690
Devlin JG, Brien T, Stephenson N (1967) Relation between antibody and insulin dose. Br Med J I: 542–544
Schlichtkrull J, Brange J, Christiansen AH, Hallund O, Heding LG, Jorgensen KH (1972) Clinical aspects of insulin-antigenicity. Diabetes 21 [Suppl 2]: 649–656
Yue DK, Turtle JR (1975) Antigenicity of “monocomponent” pork insulin in diabetic subjects. Diabetes 24: 625–632
Alberti KGMM, Nattrass M (1978) Highly purified insulins. Diabetologia 15: 77–80
Steiner DF, Hallund O, Rubenstein AH, Cho S, Bayliss C (1968) Isolation and properties of proinsulin, intermediate forms and other minor components from crystalline bovine insulin. Diabetes 17: 725–736
Chance RE, Root MA, Galloway JA (1976) The immunogenicity of insulin preparations. Acta Endocrinol (Kbh) 83 [Suppl 205]: 185–198
Kurtz AB, Matthews JA, Mustaffa BE, Daggett PR, Nabarro JDN (1980) Decrease of antibodies to insulin, proinsulin and contaminating hormones after changing treatment from conventional beef to purified pork insulin. Diabetologia 18: 147–150
Lockwood DH, Prout TE (1965) Antigenicity of heterologous and homologous insulin. Metabolism 14: 530–538
Deckert T, Grundahl E (1970) The antigenicity of pig insulin. Diabetologia 6: 15–20
Deckert T, Andersen OO, Grundahl E, Kerp L (1972) Isoimmunization of man by recrystallized human insulin. Diabetologia 8: 358–361
Berson SA, Yalow RS (1963) Antigens in insulin. Science 139: 844–845
Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA, Vijayan M (1971) Atomic positions in rhombohedral 2-Zinc insulin crystals. Nature 231: 506–511
Goldman J, Carpenter FH (1974) Zinc binding circular dichroism and equilibrium Sedimentation Studies on Insulin (bovine) and several of its derivatives. Biochemistry 13: 4566–4574
Sanger F (1960) Chemistry of insulin. Br Med Bull 16: 183–200
Albisser AM, Lougheed W, Perlman K, Bahoric A (1980) Nonaggregating insulin solutions for longterm glucose control in experimental and human diabetes. Diabetes 28: 241–243
Roitt I (1977) Essential immunology, third ed. Blackwell Scientific Publications, Oxford
Bruni B, D'Alberto M, Osenda M, Ricci C, Turco GL (1973) Clinical trial with monocomponent lente insulins. Preliminary report. Diabetologia 9: 492–498
Andreani D, Iavicoli M, Tamburrano G, Menzinger G, Maltarello C (1974) Comparative trials with monocomponent (MC) and monospecies (MS) pork insulins in the treatment of diabetes mellitus. Influence on antibody levels, on insulin requirement and some complications. Horm Metab Res 6: 447–454
Keck K (1977) Ir gene control of carrier recognition: III Cooperative recognition of two or more carrier determinants on insulins of different species. Eur J Immunol 7: 811–816
Bertrams J, Jansen FK, Grüneklee D, Reiss HE, Drost H, Beyer J, Gries FA, Kuwert E (1976) HLA-antigens and immunoresponsiveness to insulin in insulin-dependent diabetes mellitus. Tissue Antigens 8: 13–17
Nabarro JDN, Mustaffa BE, Morris DV, Walport MJ, Kurtz AB (1979) Insulin deficient diabetes. Diabetologia 16: 5–12
Baxter RC, Yue DK, Turtle JR (1976) Equilibrium binding studies of insulin antibodies in diabetic subjects. Clin Chem 22: 1089–1094
Foiling I (1976) Insulin — anti-insulin complexes. Acta Endocrinol (Kbh) 83 [Suppl 205]: 199–209
Irvine WJ, Al-Khateeb SF, DiMario U, Feek CM, Gray RS, Edmond B, Duncan LJP (1977) Soluble immune complexes in the sera of newly diagnosed insulin-dependent diabetics and in treated diabetics. Clin Exp Immunol 30: 16–21
Christiansen AH (1970) A new method for determination of insulin-binding immuno-globulins in insulin-treated diabetic patients. Horm Metab Res 2: 187–188
Gerbitz KD, Kemmler W (1978) Method for rapid quantitation and characterization of insulin antibodies. Clin Chem 24: 890–894
Kurtz AB, Matthews JA, Nabarro JDN (1978) Insulin-binding antibody: reaction differences with bovine and porcine insulins. Diabetologia 15: 19–22
Kurtz AB, Harrington MG, Matthews JA, Nabarro JDN (1979) Factitious diabetes and antibody mediated resistance to beef insulin. Diabetologia 16: 65–67
Kumar D (1979) Immunoreactivity of insulin antibodies in insulin-treated diabetics: significance of the beta-chain carboxy-terminal amino acid (B-30) of insulin. Diabetes 28: 994–100
Yalow RS, Berson SA (1964) Reactions of fish insulins with human insulin antiserum. N Engl J Med 270: 1171–1178
Poulsen JE (1967) Insulin; desirable and undesirable effects. Acta Med Scand [Suppl] 476: 91–100
Spellacy WN, Goetz FC (1963) Insulin antibodies in pregnancy. Lancet II: 222–224
Martin FI, Dahlenburg GW, Russell J, Jeffery P (1975) Neonatal hypoglycaemia in infants of insulin-dependent diabetic mothers. Arch Dis Child 50: 472–476
Nakagawa S, Suda N, Kudo M, Kawasaki M (1973) A new type of hypoglycaemia in a newborn infant. Diabetologia 9: 367–375
Kloppel G (1976) ‘Insulin’ induced insulitis. Acta Endocrinol (Kbh) 83 (Suppl 205): 107
Villalpando S, Drash A (1979) Circulating glucagon antibodies in children who have insulin-dependent diabetes mellitus. Diabetes 28: 294–299
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kurtz, A.B., Nabarro, J.D.N. Circulating insulin-binding antibodies. Diabetologia 19, 329–334 (1980). https://doi.org/10.1007/BF00280515
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00280515