Summary
Increased factor VII levels have been reported in Type 1 (insulin-dependent) diabetic subjects. A direct correlation between fasting plasma glucose and factor VII level was found to exist in both diabetic and normal subjects. Induced-hyperglycaemia was able to increase factor VII levels in both diabetic patients and normal control subjects while, when euglycaemia was achieved in diabetic patients, factor VII values returned to normal range. This study shows that the level of factor VII may be directly conditioned by circulating blood glucose and, therefore, stresses the role of hyperglycaemia in conditioning coagulation abnormalities in diabetes mellitus.
Article PDF
Similar content being viewed by others
References
Meade TW, North WRS, Chakrabart R, Stirling Y, Haines AP, Thompson SG, Brozovic M (1980) Haemostatic function and cardiovascular death: early results of a prospective study. Lancet I: 1050–1053
Balleisen L, Assmann G, Bailey J, Epping PH, Schulte H, Loo J van de (1985) Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population. Baseline data on the relation to blood pressuer, blood glucose, uric acid and lipid fractions. Thromb Haemost 54: 721–723
Jones RL, Peterson CH (1981) the fluid phase of coagulation and the accelerated atherosclerosis of diabetes mellitus. Diabetes 30 [Suppl 2]: 33–38
Ostermann H, Loo J van de (1986) Factors of the hemostatic system in diabetic patients. A survey of controlled study. Haemostasis 16: 386–416
Fearuley GB, Chakrabarti R, Avis PRD (1963) Blood fibrinolytic activity in diabetes mellitus and its bearing on ischemic heart disease and obesity. Br Med J 1: 921–932
Fuller JH, Keen H, Jarrett RJ, Omer T, Meade TW, Chakrabarti R, North WRS, Stirling Y (1979) Haemostatic variables associated with diabetes mellitus and its complications. Br Med J 2: 964–966
National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039–1057
Cerasi E, Luft R (1967) What is inherited — what is added? Hypothesis for the pathogenesis of diabetes mellitus. Diabetes 16: 615–627
Mallia AK, Hermanson GT, Krohn RS, Fujimoto EK, Smith PK (1981) Preparation and use of a boronic acid affinity chromatography for separation and quantification of glycosylated hemoglobin. Anal Letters 14: 649–661
Bertina RM, Orlando M, Tiedmann A, Alderkamp J (1979) Preparation of human factor VII deficient plasma. Thromb Res 13: 537–541
Keen H, Jarrett RJ, Fuller JH, Cartney P (1981) Hyperglycemia and arterial disease. Diabetes 30 [Suppl 2]: 49–53
Stout RW (1987) Insulin and atheroma — an updata. Lancet II: 1077–1078
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ceriello, A., Giugliano, D., Quatraro, A. et al. Blood glucose may condition factor VII levels in diabetic and normal subjects. Diabetologia 31, 889–891 (1988). https://doi.org/10.1007/BF00265372
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00265372