Abstract
• Background: Basal cell carcinoma (BCC) is the most common of all malignant tumours and often appears on the periocular skin. In the present study, patients with 166 eyelid and periocular BCCs were treated with cryotherapy at the Eye Clinic of the Kuopio University Hospital. Seven patients with a total of eight BCCs died during the first year after cryotherapy, of causes unrelated to BCC. These cases were excluded from the analysis of outcome. • Method: The tumours were photographed before excisional biopsy and histopathological examination. The BCCs were frozen twice with liquid nitrogen in a closed cryoprobe; a tissue thermometer was used. • Results: During the mean follow-up of 5 years for 158 BCCs, recurrences were observed in 12 cases (7.6%). The most important prognostic factors for recurrence were large tumour size (maximum diameter exceeding 10 mm), tumour extension into the lid margin, and cicatrising (morpheaform) BCC. The complications of cryotherapy were slight, but in some cases lid ectropion needed surgical correction. The functional and cosmetic results were very satisfactory in most cases. • Conclusion: Ninety-two percent of BBCs treated with cryotherapy did not recur during mean follow-up of 5.0 years (range 1.6–8.4 years).
Similar content being viewed by others
References
Beard C (1981) Management of malignancy of the eyelids. Am J Ophthalmol 92:1–6
Biro L, Price E (1990) Cryosurgical management of basal cell carcinoma of the eyelid: a 10-year experience. J Am Acad Dermatol 23:316–317
Braverman IM, Fonferko E (1982) Studies in cutaneous aging. 1. The elastic fiber network. J Invest Dermatol 78:434–443
Fraunfelder FT, Zacarian SA, Wingfield DL, Limmer BL (1984) Results of cryotherapy for eyelid malignancies. Am J Ophthalmol 97:184–188
Gunnarson G, Larkö O, Hersle K (1990) Cryosurgery of eyelid basal cell carcinomas. Acta Ophthalmol 68:241–245
Hauben DJ, Zirkin H, Mahler D, Sacks M (1982) The biologic behavior of basal cell carcinoma, art I. Plast Reconstr Surg 69:103–109
Hauben DJ, Zirkin H, Mahler D, Sacks M (1982) The biologic behavior of basal cell carcinoma. II. Analysis of recurrence in excised basal cell carcinoma. Plast Reconstr Surg 69:110–116
Hönigsmann H, Jaenicke KF, Brenner W, Rauschmeier W, Parrish JA (1981) Unscheduled DNA synthesis in normal human skin after single and combined doses of UVA, UVB and UVA with methoxsalen (PUVA). Br J Dermatol 105:491–501
Kuflik EG (1985) Cryosurgery for carinoma of the eyelids: a 12-year experience. J Dermatol Surg Oncol 11:243–246
Kuflik EG, Webb W (1985) Effects of systemic corticosteroids on postcryosurgical edema and other manifestations of the inflammatory response. J Dermatol Surg Oncol 11:464–468
Margo CE, Waltz K (1993) Basal cell carcinoma of the eyelid and periocular skin. Major review. Surv Ophthalmol 38:169–192
Matthdus W, Sebastian G, Scholz A (1977) Die Kryotherapie des Basalioms. Arch Geschwulstforsch 47/5:412–420
Matthäus W (1987) 15 jährige Erfahrungen mit der Kryotherapie von Lid-, Geschichts- und Bindehauttumoren in 2745 Fällen. Fortschr Ophthalmol 84:568–576
Oikarinen A, Kallioinen M (1989) A biochemical and immunohistochemical study of collagen in sun-exposed and protected skin. Photodermatol 6:24–31
Prskavec FH (1986) Indikation und Ergebnisse der Kryotherapie von Lidtumoren. Wien Klin Wochenschr 98:279–281
Purdy EP, Bullock JD (1991) Eyelid tumors. Curr Opin Ophthalmol 2:271–280
Scholda C, Collin JRO (1990) Value of histological clearance of eyelid basal cell carcinomas. Orbit 9:3–5
Tuppurainen K (1990) Cryotherapy for malignancies of the eyelid. Acta Ophthalmol [Suppl 195] 68:75–78
Zacarian SA (1980) Cryosurgery for malignant tumors of the eyelids. Ann Ophthalmol 12:285–288
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tuppurainen, K. Cryotherapy for eyelid and periocular basal cell carcinomas: outcome in 166 cases over an 8-year period. Graefe's Arch Clin Exp Ophthalmol 233, 205–208 (1995). https://doi.org/10.1007/BF00183593
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00183593