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Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link?

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Aldehyde Dehydrogenases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1193))

Abstract

Aging is a complex irreversible biological process associated with increased prevalence of chronic disease and high healthcare burden. Several theories have been proposed for the biology of aging including free radical accumulation, DNA damage, apoptosis, telomere shortening, autophagy failure, and disturbed autonomic response. Aging is also closely associated with progressive deterioration of cardiovascular and neurological functions. Linkage, genome-wide association (GWAS), and next-generation sequencing analysis have confirmed a number of susceptibility loci for aging, in particular, Alzheimer’s disease. Recent evidence from our group and others also revealed a tie between genetic mutation of mitochondrial aldehyde dehydrogenase (ALDH2) and life span as well as cardiovascular aging. ALDH2 represents the single most gene with the greatest number of human genetic polymorphism and is deemed an important enzyme for detoxification of reactive aldehydes. Here, we will briefly review the tie between ALDH2 and cardiovascular aging process. While recent work on ALDH2 research has broadened the pathogenic mechanisms of ALDH2 mutation or deficiency, therapeutic potential targeting ALDH2 in the elderly still remains debatable.

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Acknowledgments

This work was supported in part by NSFC91749128. We wish to express our apology for those authors whose important work was unable to be included due to space limitation.

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Authors and Affiliations

  1. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Ne Natalie Wu & Jun Ren

  2. Center for Cardiovascular Research and Alternative Medicine,, University of Wyoming College of Health Sciences, Laramie, WY, USA

    Jun Ren

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  1. Ne Natalie Wu
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Correspondence to Jun Ren .

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Editors and Affiliations

  1. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Jun Ren

  2. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Yingmei Zhang

  3. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Junbo Ge

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Wu, N.N., Ren, J. (2019). Aldehyde Dehydrogenase 2 (ALDH2) and Aging: Is There a Sensible Link?. In: Ren, J., Zhang, Y., Ge, J. (eds) Aldehyde Dehydrogenases. Advances in Experimental Medicine and Biology, vol 1193. Springer, Singapore. https://doi.org/10.1007/978-981-13-6260-6_15

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