Abstract
In this chapter we will discuss the relative risk of toxic (pigment) nephropathy in certain disease states. We will discuss the specific complication associated with uric acid, rhabdomyolysis, as well as that associated with tumor lysis syndrome. This section will also discuss the relative approaches to prevention and intervention if necessary.
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References
Tsuji T, Ohishi K, Takeda A, et al. The impact of serum uric acid reduction on renal function and blood pressure in chronic kidney disease patients with hyperuricemia. Clin Exp Neprhol. 2018. https://doi.org/10.1007/s10157-018-1580-4.
Xu X, Hu J, Song N, et al. Hyperuricemia increases the risk of acute kidney injury: a systematic review and meta-analysis. BMC Nephrol. 2017;18:27.
Goldman SC, Holcenberg JS, Finklestein JZ, et al. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood. 2001;97:2998–3003.
Hobbs DJ, Steinke J, Chung J, et al. Rasburicase improves hyperuricemia in infants with acute kidney injury. Pediatr Nephrol. 2010;25:305–9.
Feig DI. Serum uric acid and the risk of hypertension and chronic kidney disease. Curr Opin Rheumatol. 2014;26(2):176–85.
Al-Ismaili Z, Piccioni M, Zappitelli M. Rhabdomyolysis: pathogenesis of renal injury and management. Pediatr Nephrol. 2011;26:1781–8.
Mannix R, Tan ML, Wright R, et al. Acute pediatric rhabdomyolysis: cause and rates of renal failure. Pediatrics. 2006;118:2119–25.
Eneas JF, Schoenfeld PY, Humphreys MH. The effect of infusion of mannitol-sodium bicarbonate on the clinical course of myoglobinuria. Arch Intern Med. 1979;139:801–5.
Naka T, Jones D, Baldwin I, et al. Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report. Crit Care. 2005;9:R90–5.
Prusakowski MK, Cannone D. Pediatric oncologic emergencies. Hematol Oncol Clin N Am. 2017;31:959–80.
Nguyen T, Ondrik D, Zhufyak O, et al. Hyperkalemia and potential pitfalls of sodium polystyrene sulfonate. JAAPA. 2015;28(3):41–5.
Bakir AA. The fatal interplay of aluminum and citrate in chronic renal failure: a lesson from three decades ago. Artif Organs. 2015;39(2):87–9.
Sinha R, Sethi SK, Bunchman T, et al. Prolonged intermittent renal replacement therapy in children. Pediatr Nephrol. 2018;33(8):1283–96.
Sakarcan A, Quigley R. Hyperphosphatemia in tumor lysis syndrome: the role of hemodialysis and continuous veno-venous hemofiltration. Pediatr Nephrol. 1994;8(3):351–3.
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Bunchman, T.E. (2019). Toxic Nephropathy: Uric Acid, Rhabdomyolysis, and Tumor Lysis Syndrome. In: Sethi, S., Raina, R., McCulloch, M., Bunchman, T. (eds) Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook. Springer, Singapore. https://doi.org/10.1007/978-981-13-2276-1_26
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DOI: https://doi.org/10.1007/978-981-13-2276-1_26
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