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Toxic Nephropathy: Uric Acid, Rhabdomyolysis, and Tumor Lysis Syndrome

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Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook

Abstract

In this chapter we will discuss the relative risk of toxic (pigment) nephropathy in certain disease states. We will discuss the specific complication associated with uric acid, rhabdomyolysis, as well as that associated with tumor lysis syndrome. This section will also discuss the relative approaches to prevention and intervention if necessary.

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References

  1. Tsuji T, Ohishi K, Takeda A, et al. The impact of serum uric acid reduction on renal function and blood pressure in chronic kidney disease patients with hyperuricemia. Clin Exp Neprhol. 2018. https://doi.org/10.1007/s10157-018-1580-4.

    Article  CAS  Google Scholar 

  2. Xu X, Hu J, Song N, et al. Hyperuricemia increases the risk of acute kidney injury: a systematic review and meta-analysis. BMC Nephrol. 2017;18:27.

    Article  Google Scholar 

  3. Goldman SC, Holcenberg JS, Finklestein JZ, et al. A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood. 2001;97:2998–3003.

    Article  CAS  Google Scholar 

  4. Hobbs DJ, Steinke J, Chung J, et al. Rasburicase improves hyperuricemia in infants with acute kidney injury. Pediatr Nephrol. 2010;25:305–9.

    Article  Google Scholar 

  5. Feig DI. Serum uric acid and the risk of hypertension and chronic kidney disease. Curr Opin Rheumatol. 2014;26(2):176–85.

    Article  CAS  Google Scholar 

  6. Al-Ismaili Z, Piccioni M, Zappitelli M. Rhabdomyolysis: pathogenesis of renal injury and management. Pediatr Nephrol. 2011;26:1781–8.

    Article  Google Scholar 

  7. Mannix R, Tan ML, Wright R, et al. Acute pediatric rhabdomyolysis: cause and rates of renal failure. Pediatrics. 2006;118:2119–25.

    Article  Google Scholar 

  8. Eneas JF, Schoenfeld PY, Humphreys MH. The effect of infusion of mannitol-sodium bicarbonate on the clinical course of myoglobinuria. Arch Intern Med. 1979;139:801–5.

    Article  CAS  Google Scholar 

  9. Naka T, Jones D, Baldwin I, et al. Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case report. Crit Care. 2005;9:R90–5.

    Article  Google Scholar 

  10. Prusakowski MK, Cannone D. Pediatric oncologic emergencies. Hematol Oncol Clin N Am. 2017;31:959–80.

    Article  Google Scholar 

  11. Nguyen T, Ondrik D, Zhufyak O, et al. Hyperkalemia and potential pitfalls of sodium polystyrene sulfonate. JAAPA. 2015;28(3):41–5.

    Article  Google Scholar 

  12. Bakir AA. The fatal interplay of aluminum and citrate in chronic renal failure: a lesson from three decades ago. Artif Organs. 2015;39(2):87–9.

    Article  Google Scholar 

  13. Sinha R, Sethi SK, Bunchman T, et al. Prolonged intermittent renal replacement therapy in children. Pediatr Nephrol. 2018;33(8):1283–96.

    Article  Google Scholar 

  14. Sakarcan A, Quigley R. Hyperphosphatemia in tumor lysis syndrome: the role of hemodialysis and continuous veno-venous hemofiltration. Pediatr Nephrol. 1994;8(3):351–3.

    Article  CAS  Google Scholar 

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Correspondence to Timothy E. Bunchman .

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Bunchman, T.E. (2019). Toxic Nephropathy: Uric Acid, Rhabdomyolysis, and Tumor Lysis Syndrome. In: Sethi, S., Raina, R., McCulloch, M., Bunchman, T. (eds) Critical Care Pediatric Nephrology and Dialysis: A Practical Handbook. Springer, Singapore. https://doi.org/10.1007/978-981-13-2276-1_26

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  • DOI: https://doi.org/10.1007/978-981-13-2276-1_26

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-2275-4

  • Online ISBN: 978-981-13-2276-1

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