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Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Proteinase activated receptors (PARs), a small subfamily of G protein-coupled receptors with four members, PAR1, PAR2, PAR3 and PAR4, are expressed in various tumours from epithelial origin and can play an important role in tumour progression and metastasis. Within the complex intracellular PAR signaling networks triggered by PARs, an elevation in intracellular free calcium ion concentrations represents a key second messenger system. In this review, we summarize current information about the mechanisms whereby PARs can signal via intracellular calcium in the setting of cancer and we discuss possibilities for using the PAR-[Ca2+]i signaling pathway as a target for the therapy of epithelial cancer.

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Acknowledgements

Work in the author’s laboratories is supported by grants from German Cancer Aid (RK) and German Research Foundation (RK), the Canadian Institutes for Health Research (MDH) and the Heart & Stroke Foundation of Alberta and Nunavut (MDH). We are grateful for the referee’s comments which have helped with the writing of this article.

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Authors and Affiliations

  1. Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital, Erlanger Allee 101, D-07747, Jena, Germany

    Roland Kaufmann

  2. Inflammation Research Network, Department of Physiology & Pharmacology and Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1

    Morley D. Hollenberg

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  1. Roland Kaufmann
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Correspondence to Roland Kaufmann .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Kaufmann, R., Hollenberg, M.D. (2012). Proteinase-Activated Receptors (PARs) and Calcium Signaling in Cancer. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_45

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