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Neurotoxicity of Combined Radiation and Chemotherapy

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Neurological Adverse Reactions to Anticancer Drugs

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

Most observers believe that when radiation therapy to the central nervous system is combined with either systemic or intrathecal chemotherapy, neurotoxicity is more likely to result than when either of these modalities is used alone. The evidence for such synergism is best established for methotrexate but other chemotherapeutic agents have also been implicated (Table 1).

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Authors and Affiliations

  1. Clinical Research Department, Duphar BV, C.J. van Houtenlaan 36, 1381 CP, Weesp, The Netherlands

    Roland Gerritsen van der Hoop

  2. Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    Lisa M. DeAngelis & Jerome B. Posner

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  1. Roland Gerritsen van der Hoop
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  2. Lisa M. DeAngelis
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  3. Jerome B. Posner
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Editors and Affiliations

  1. Service de Neurologie, Hôpital Erasme Université Libre de Bruxelles, Route de Lennik, 808, 1070, Bruxelles, Belgium

    Jerzy Hildebrand

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© 1990 Springer-Verlag Berlin Heidelberg

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van der Hoop, R.G., DeAngelis, L.M., Posner, J.B. (1990). Neurotoxicity of Combined Radiation and Chemotherapy. In: Hildebrand, J. (eds) Neurological Adverse Reactions to Anticancer Drugs. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76142-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-76142-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76144-7

  • Online ISBN: 978-3-642-76142-3

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