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Development and Resolution of Ischemic Brain Swelling

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Dynamics of Brain Edema

Summary

The pathomechanism of ischemic brain swelling was studied in cats following 1 h of complete ischemia of the total brain. Brain water after ischemia increased from 75.9 to 78.3 ml/100 g, accompanied by an increase in intracranial pressure to 45 mm Hg and a displacement of the cortical surface by 270 µ. Extracellular space during ischemia decreased from 18.9 to 8.5 vol %, and expanded to more than 18% upon recirculation. Post-ischemic brain swelling was due to vasoparalysis and to the equilibration of osmotic and ionic gradients between extracellular fluid and blood. Upon reactivation of the energy-producing metabolism, brain swelling was reversible within 2–3 h.

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Authors and Affiliations

  1. The Max-Planck-Institute for Brain Research, Cologne, W. Germany

    K. A. Hossmann

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  1. K. A. Hossmann
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Editors and Affiliations

  1. Dept. of Neurology and Neurosurgery, McGill University, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

  2. Montreal Neurological Institute, 3801 University Street, H3A 2B4, Montreal, Que., Canada

    Hanna M. Pappius Ph. D. (Associate Professor, Associate Neurochemist) & William Feindel M. D., D. Phil., F.R.S.C. (Professor, Director) (Associate Professor, Associate Neurochemist) &  (Professor, Director)

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© 1976 Springer-Verlag Berlin · Heidelberg

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Hossmann, K.A. (1976). Development and Resolution of Ischemic Brain Swelling. In: Pappius, H.M., Feindel, W. (eds) Dynamics of Brain Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66524-0_35

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  • DOI: https://doi.org/10.1007/978-3-642-66524-0_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-08009-1

  • Online ISBN: 978-3-642-66524-0

  • eBook Packages: Springer Book Archive

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