Abstract
The healing process is dynamic and involves complex events that include hemostasis, inflammation, granulation tissue formation, epithelialization, neovascularization, collagen synthesis, and wound contraction. Several experimental clinical studies have demonstrated the reduction of growth factors of chronic wounds. Platelet aggregation has the leading role in the process of skin healing since it is responsible for releasing growth factors, adhesion molecules and lipids, which regulate migration, proliferation and function of keratinocytes, fibroblasts and endothelial cells. The platelet-leukocyte gel (L-PRP), besides releasing the growth factors that start tissue regeneration, can also strengthen the antimicrobial activity, which shows its potential as an infection prevention and treatment agent. PRP is a powerful weapon for treating chronic ulcers, providing healing, reducing infection rates, besides its preventive action, which reduces amputation rates.
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Cancela, A.M., Lana, J.F., Annichino-Bizzachi, J.M., Belangero, W.D., Luzo, Â.C.M. (2014). Use of Platelet-Rich Plasma (PRP) in Treating Chronic Wounds. In: Lana, J., Andrade Santana, M., Dias Belangero, W., Malheiros Luzo, A. (eds) Platelet-Rich Plasma. Lecture Notes in Bioengineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40117-6_15
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DOI: https://doi.org/10.1007/978-3-642-40117-6_15
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