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Role of Complement on Broken Surfaces After Trauma

  • Conference paper
Immune Responses to Biosurfaces

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 865))

Abstract

Activation of both the complement and coagulation cascade after trauma and subsequent local and systemic inflammatory response represent a major scientific and clinical problem. After severe tissue injury and bone fracture, exposure of innate immunity to damaged cells and molecular debris is considered a main trigger of the posttraumatic danger response. However, the effects of cellular fragments (e.g., histones) on complement activation remain enigmatic. Furthermore, direct effects of “broken” bone and cartilage surfaces on the fluid phase response of complement and its interaction with key cells of connective tissues are still unknown. Here, we summarize data suggesting direct and indirect complement activation by extracellular and cellular danger associated molecular patterns. In addition, key complement components and the corresponding receptors (such as C3aR, C5aR) have been detected on “exposed surfaces” of the damaged regions. On a cellular level, multiple effects of complement activation products on osteoblasts, osteoclasts, chondrocytes and mesenchymal stem cells have been found.

In conclusion, the complement system may be activated by trauma-altered surfaces and is crucially involved in connective tissue healing and posttraumatic systemic inflammatory response.

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Acknowledgments

The cited author’s own work was funded in part by the State of Baden-Württemberg (Perspektivförderung), the DFG Clinical Research Unit KFO200 TP2 and TP4, and the SFB1149.

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Authors and Affiliations

  1. Department of Orthopedic Trauma, Hand-, Plastic-, and Reconstructive Surgery, University of Ulm, Ulm, Germany

    Markus Huber-Lang

  2. Institute of Orthopedic Research and Biomechanics, University of Ulm, Ulm, Germany

    Anita Ignatius

  3. Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopedics, University of Ulm, Ulm, Germany

    Rolf E. Brenner

Authors
  1. Markus Huber-Lang
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  2. Anita Ignatius
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  3. Rolf E. Brenner
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Correspondence to Markus Huber-Lang .

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Editors and Affiliations

  1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    John D. Lambris

  2. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

    Kristina N. Ekdahl

  3. Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Daniel Ricklin

  4. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

    Bo Nilsson

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Huber-Lang, M., Ignatius, A., Brenner, R.E. (2015). Role of Complement on Broken Surfaces After Trauma. In: Lambris, J., Ekdahl, K., Ricklin, D., Nilsson, B. (eds) Immune Responses to Biosurfaces. Advances in Experimental Medicine and Biology, vol 865. Springer, Cham. https://doi.org/10.1007/978-3-319-18603-0_3

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