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Principles of Musculoskeletal Biopsy

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Orthopaedic Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 162))

Abstract

The appropriate treatment of any musculoskeletal tumor is based on a correct diagnosis. In some instances, a patient’s history and imaging studies provide sufficient information to guide definitive treatment. However, in many cases, a biopsy may be necessary. A biopsy, although technically simple, must be conducted in a thoughtful manner in order to obtain an accurate tissue sample while avoiding complications. Some potential complications include inaccurate sampling, improperly placed incision that complicates future surgeries, and healthy tissue contamination that can add morbidity to the definitive surgery or preclude the chance of limb salvage. This chapter will review the considerations for planning and performing a biopsy of musculoskeletal tumors.

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References

  1. Demas BE, Heelan RT, Lane J, Marcove R, Hajdu S, Brennan MF (1988) Soft-tissue sarcomas of the extremities: comparison of MR and CT in determining the extent of disease. AJR Am J Roentgenol 150(3):615–620

    Article  CAS  PubMed  Google Scholar 

  2. Simon MA (1982) Biopsy of musculoskeletal tumors. J Bone Joint Surg Am 64(8):1253–1257

    Google Scholar 

  3. Mankin HJ, Mankin CJ, Simon MA (1996) The hazards of the biopsy, revisited. Members of the musculoskeletal tumor society. J Bone Joint Surg Am 78(5):656–666

    Google Scholar 

  4. Skrzynski MC, Biermann JS, Montag A, Simon MA (1996) Diagnostic accuracy and charge-savings of outpatient core needle biopsy compared with open biopsy of musculoskeletal tumors. J Bone Joint Surg Am 78(5):644–649

    Google Scholar 

  5. Welker JA, Henshaw RM, Jelinek J, Shmookler BM, Malawer MM (2000) The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses. Cancer 89(12):2677–2686

    Article  CAS  PubMed  Google Scholar 

  6. Costa MJ, Campman SC, Davis RL, Howell LP (1996) Fine-needle aspiration cytology of sarcoma: retrospective review of diagnostic utility and specificity. Diagn Cytopathol 15(1):23–32

    Article  CAS  PubMed  Google Scholar 

  7. Simon MA, Biermann JS (1993) Biopsy of bone and soft-tissue lesions. J Bone Joint Surg Am 75(4):616–621

    Google Scholar 

  8. Heslin MJ, Lewis JJ, Woodruff JM, Brennan MF (1997) Core needle biopsy for diagnosis of extremity soft tissue sarcoma. Ann Surg Oncol 4(5):425–431

    Article  CAS  PubMed  Google Scholar 

  9. Yang YJ, Damron TA (2004) Comparison of needle core biopsy and fine-needle aspiration for diagnostic accuracy in musculoskeletal lesions. Arch Pathol Lab Med 128(7):759–764

    PubMed  Google Scholar 

  10. Pohlig F, Kirchhoff C, Lenze U, Schauwecker J, Burgkart R, Rechl R, von Eisenhart-Rothe R (2012) Percutaneous core needle biopsy versus open biopsy in diagnostics of bone and soft tissue sarcoma: a retrospective study. Eur J Med Res 17(29):7

    Google Scholar 

  11. Khoja H, Griffin A, Dickson B et al (2013) Sampling modality influences the predictive value of grading in adult soft tissue extremity sarcomas. Arch Pathol Lab Med 137(12):1774–1779

    Article  PubMed  Google Scholar 

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Correspondence to Raffi S. Avedian .

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© 2014 Springer International Publishing Switzerland

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Avedian, R.S. (2014). Principles of Musculoskeletal Biopsy. In: Peabody, T., Attar, S. (eds) Orthopaedic Oncology. Cancer Treatment and Research, vol 162. Springer, Cham. https://doi.org/10.1007/978-3-319-07323-1_1

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  • DOI: https://doi.org/10.1007/978-3-319-07323-1_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-07322-4

  • Online ISBN: 978-3-319-07323-1

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