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A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E)

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Progress in Drug Research

Part of the book series: Progress in Drug Research ((PDR,volume 59))

Summary

New treatments for psychiatric disorders are urgently required. Recent reviews show that there have been no improvements in efficacy of drugs for either affective disorders or schizophrenia since the first compounds were introduced over 40 years ago. Neuroactive lipids represent an entirely novel class of psychotropic compounds. Ethyl eicosapentaenoate is the first example of this group. Placebo-controlled studies have found it to be effective in depression, in treatment-unresponsive schizophrenia and in tardive dyskinesia. It is extremely well tolerated with none of the usual side-effects of either antidepressants or neuroleptics. It probably works by modulating post-receptor signal transduction processes.

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    David F. Horrobin

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Horrobin, D.F. (2002). A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E). In: Jucker, E. (eds) Progress in Drug Research. Progress in Drug Research, vol 59. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8171-5_6

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  • DOI: https://doi.org/10.1007/978-3-0348-8171-5_6

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