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Regulation of Lymphocytes by Nitric Oxide

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Suppression and Regulation of Immune Responses

Part of the book series: Methods in Molecular Biology ((MIMB,volume 677))

Abstract

Shortly after the identification of nitric oxide (NO) as a product of macrophages, it was discovered that NO generated by inducible NO synthase (iNOS) inhibits the proliferation of T lymphocytes. Since then, it has become clear that iNOS activity also regulates the development, differentiation, and/or function of various types of T cells and B cells and also affects NK cells. The three key mechanisms underlying the iNOS-dependent immunoregulation are (a) the modulation of signaling processes by NO, (b) the depletion of arginine, and (c) the alteration of accessory cell functions. This chapter highlights important principles of iNOS-dependent immunoregulation of lymphocytes and also reviews more recent evidence for an effect of endothelial or neuronal NO synthase in lymphocytes.

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Acknowledgments

I wish to apologize to all researchers whose work could only be cited in form of review articles due to space restrictions. The preparation of this chapter and the conduct of some of the studies reviewed were supported by grants to C.B. from the Deutsche Forschungsgemeinschaft (Bo996/3-3, SFB643 A6) and from the IZKF Erlangen (Project A24).

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  1. Medical Microbiology and Immunology of Infectious Diseases, Microbiology Institute – Clinical Microbiology, Immunology and Hygiene, Friedrich-Alexander-University Erlangen-Nuremberg and University Clinic of Erlangen, Erlangen, Germany

    Christian Bogdan

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  1. CHUHotel Dieu, INSERM UMR 643, Bd. Jean Monnet 30, Nantes, 44093, France

    Maria Cristina Cuturi

  2. CHU Hotel Dieu, INSERM UMR 643, Bd. Jean Monnet 30, Nantes, 44093, France

    Ignacio Anegon

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Bogdan, C. (2010). Regulation of Lymphocytes by Nitric Oxide. In: Cuturi, M., Anegon, I. (eds) Suppression and Regulation of Immune Responses. Methods in Molecular Biology, vol 677. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-869-0_24

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  • DOI: https://doi.org/10.1007/978-1-60761-869-0_24

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