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Acute Lymphocytic Leukemia – Clinical Features and Making the Diagnosis

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Adult Acute Lymphocytic Leukemia

Part of the book series: Contemporary Hematology ((CH))

Abstract

The clinical presentation of acute lymphocytic leukemia (ALL) may range from insidious nonspecific symptoms to severe acute life-threatening manifestations, reflecting the extent of bone marrow involvement and degree of extramedullary spread (Table 2.1). In younger patients anemia-induced fatigue may be the only presenting feature. Dyspnea, angina, dizziness, and lethargy may reflect the degree of anemia in older patients presenting with ALL. Approximately half of all patients may present with fever attributable to the pyrogenic cytokines, such as IL-1, IL-6, TNF, released from the leukemic cells, infection, or both.

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  1. Department of Medicine and Pathology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

    Olga Frankfurt, LoAnn Petersen & Martin S. Tallman

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  1. Cleveland Clinic Foundation, Euclid Ave. 9500, Cleveland, 44195, Ohio, USA

    Anjali S. Advani

  2. School of Medicine, University Hospitals of Cleveland, Euclid Avenue 11100, Cleveland, 44106, Ohio, USA

    Hillard M. Lazarus

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Frankfurt, O., Petersen, L., Tallman, M.S. (2011). Acute Lymphocytic Leukemia – Clinical Features and Making the Diagnosis. In: Advani, A., Lazarus, H. (eds) Adult Acute Lymphocytic Leukemia. Contemporary Hematology. Humana Press. https://doi.org/10.1007/978-1-60761-707-5_2

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