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Hypertrophic Scarring in the Rabbit Ear: A Practical Model for Studying Dermal Fibrosis

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Fibrosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1627))

Abstract

Excessive fibrous tissue deposition after injury in the form of hypertrophic scar remains a major clinical challenge. The development of an animal model for such scarring has been extremely difficult because of a major difference between the healing process in laboratory animals and humans. Here, we describe the rabbit ear model for excessive dermal scarring which has some clinical and histological resemblance to human hypertrophic scar. Since its development, this model has been widely used to study the cellular and molecular biology of hypertrophic scarring and evaluate the efficacy of new therapeutic agents.

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Author information

Authors and Affiliations

  1. Burn and Wound Healing Laboratory, Department of Surgery, Division of Plastic Surgery, University of British Columbia, Vancouver, BC, Canada

    Layla Nabai (BC Professional Firefighters’) & Aziz Ghahary (BC Professional Firefighters’)

Authors
  1. Layla Nabai
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  2. Aziz Ghahary
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Corresponding author

Correspondence to Aziz Ghahary .

Editor information

Editors and Affiliations

  1. Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Laure Rittié

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Nabai, L., Ghahary, A. (2017). Hypertrophic Scarring in the Rabbit Ear: A Practical Model for Studying Dermal Fibrosis. In: Rittié, L. (eds) Fibrosis. Methods in Molecular Biology, vol 1627. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7113-8_6

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  • DOI: https://doi.org/10.1007/978-1-4939-7113-8_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7112-1

  • Online ISBN: 978-1-4939-7113-8

  • eBook Packages: Springer Protocols

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