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Aberrations of the G1- and G1/S-regulating genes in human cancer

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Deregulated cell proliferation is the hallmark of cancer, and convergent data from the fields of cell-cycle research and molecular oncology have revealed the key role played by abnormalities of the cell-cycle control genes in multistep tumorigenesis. Along with the p53-mediated DNA damage checkpoint, the G1-governing pathway of D-type cyclins, their partner cyclin-dependent kinases (Cdk), Cdk inhibitors, and the retinoblastoma protein constitute a functional unit and prominent oncogenic target We have learned a great deal about the molecular basis of G1 phase progression and G1/S transition, their proto-oncogenic defects, and potential clinical significance including diagnostic and prognostic applications and new approaches to gene therapy of cancer.

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Authors and Affiliations

  1. Department of Cell Cycle and Cancer, Division of Cancer Biology, Danish Cancer Society, Copenhagen, DK-2100, Denmark

    Jirina Bartkova, Jiri Lukas & Jiri Bartek

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  1. Jirina Bartkova
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  2. Jiri Lukas
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  3. Jiri Bartek
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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Silvana Guidet  & 

  2. Centre National de la Recherche Scientifique, Université de Rennes I, Rennes, France

    Michel Philippe

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Bartkova, J., Lukas, J., Bartek, J. (1997). Aberrations of the G1- and G1/S-regulating genes in human cancer. In: Meijer, L., Guidet, S., Philippe, M. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5371-7_16

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  • DOI: https://doi.org/10.1007/978-1-4615-5371-7_16

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