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Cytokines and Tear Function in Ocular Surface Disease

  • Chapter
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

Abstract

It is likely that rates of tear production and turnover are important in determining the cytokine environment of ocular surface tissues, by supplying cytokines in tear fluid and by clearing those produced at the ocular surface. Epidermal growth factor (EGF), which is released into tear fluid by the lacrimal gland,1–4 influences healing of corneal epithelial and conjunctival wounds.5–10 These concentrations vary inversely with reflex tear secretion,3,4 but under normal conditions in vivo, the relationships between tear concentrations of EGF and other variables such as age, gender, tear production, and clearance have not been examined. This information potentially could contribute to a better understanding of the role of EGF in maintenance of ocular surface integrity under normal circumstances, so in the first part (Tear EGF Concentrations in Normals) of a two-part study, we examined these influences in a large group of normal subjects.11

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Author information

Authors and Affiliations

  1. Corneal and External Disease Service Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA

    Keith Barton, Alexandra Nava, Dagoberto C. Monroy & Stephen C. Pflugfelder

  2. Moorfields Eye Hospital, London, England, UK

    Keith Barton

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  1. Keith Barton
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  2. Alexandra Nava
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  3. Dagoberto C. Monroy
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  4. Stephen C. Pflugfelder
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Editor information

Editors and Affiliations

  1. The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  2. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Michele A. Meneray

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© 1998 Springer Science+Business Media New York

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Barton, K., Nava, A., Monroy, D.C., Pflugfelder, S.C. (1998). Cytokines and Tear Function in Ocular Surface Disease. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_64

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_64

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

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