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Clinical significance of erbB2 protein overexpression

  • Chapter
Genes, Oncogenes, and Hormones

Part of the book series: Cancer Treatment and Research ((CTAR,volume 61))

Abstract

Originally described as a homologue of the EGF receptor gene amplified in breast cancer [1], erbB-2 protein is now thought to be a cell membrane receptor for a newly described ligand-gp30 [2]. There is some confusion in the literature about the terminology for erbB-2. In brief, erbB-2, c-erbB-2, and HER-2 refer to the same human gene residing in the long arm of the chromosome 17, which has homology to human EGF receptor gene (c-erbB) [3]. erbB-2 protein, p185erbB-2, or p185HER-2 refer to the transmembrane receptor protein translated from the erbB-2 gene, which has a molecular weight of 185 kDa. c-neu refers to the rat counterpart of the erbB-2 gene [4].

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Authors
  1. Soonmyoung Paik
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  2. Elizabeth Burkhard
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  3. Marc E. Lippman
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Editor information

Editors and Affiliations

  1. Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, D.C., USA

    Robert B. Dickson  & Marc E. Lippman  & 

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Paik, S., Burkhard, E., Lippman, M.E. (1991). Clinical significance of erbB2 protein overexpression. In: Dickson, R.B., Lippman, M.E. (eds) Genes, Oncogenes, and Hormones. Cancer Treatment and Research, vol 61. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3500-3_9

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  • DOI: https://doi.org/10.1007/978-1-4615-3500-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6552-5

  • Online ISBN: 978-1-4615-3500-3

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