Abstract
Metastatic frequency to various organ sites in 137 autopsy cases with histologically confirmed prostatic adenocarcinoma was examined retrospectively. Bone lymph node metastases were observed in 81% and 82.5% of the cases, respectively. Lung and liver metastases were noted in 46.7% and 30.7% of the cases respectively. Statistical analysis of the inter-relation among metastases to the bones, lymph nodes, lungs and liver revealed that 83.2% of cases with lymph node metastasis also had bone metastasis. Sixty out of 64 cases with lung metastasis also presented with bone metastasis. There was a significant correlation of metastases between bones and lymph nodes, bones and lungs, and lymph nodes and lungs. Although approximately 88% of cases with liver metastasis also had bone metastasis, this relationship was not statistically significant. there was a statistically significant relationship between lung metastasis and specific sites of bone metastases, i.e. vertebrae, ribs, and sternum. Using the Cochran-Mantel-Haenszel statistical method, we found that the metastatic combination between lung and bone was significantly related in cases with or without lymph node metastasis. These observations suggest that the Batson’s vertebral system might play an important role in the metastatic spread of prostatic adenocarcinoma either to the bones or lungs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Glaves D., Mechanisms of metastasis: prostate cancer, in: “Current Concepts and Approaches to the Study of Prostate Cancer”, pp 329–345, Liss Inc., New York (1987).
Mintz E.R., Smith G.G., Autopsy findings in 100 cases of prostatic cancer, New Eng. J. Med. 211:479–487 (1934).
Arhheim F.K., Carcinoma of the prostate: A study of the postmortem findings in one hundred and seventy-six cases, J. Urol. 60:599–603 (1948).
Elkins M., Mueller H.P., Metastases from cancer of the prostate. Autopsy and roentgenological findings, Cancer 7:1246–1248 (1954).
Franks L.M., The spread of prostatic cancer, J. Pathol. Bad. 72:603–611 (1956).
Saitoh H., Hida M., Shimbo T., Makamura K., Yamagata J., Satoh T., Metastatic patterns of prostatic cancer, Cancer 54:3078–3084 (1984).
Jacobs S.C., Spread of prostatic cancer to bone, Urology 21:337–344 (1983).
Coman D.R., and de Long R.P., The role of the vertebral venous system in the metastasis of cancer to the spinal column, Cancer 4:610–618 (1951).
Batson O.V., The function of the vertebral veins and their role in the spread of metastases, Ann. Surg. 112:138–149 (1940).
Franks L.M., The spread of prostatic carcinoma to the bones, J. Pathol. Bact. 66:91–93 (1953).
Dodds P.R., Caride V.J., Lytton B., The role of vertebral veins in the dissemination of prostatic carcinoma, J. Urol. 126:753–755 (1981).
Japanese Urological Association and The Japanese Pathological Society: “General Rule for Clinical and Pathological Studies on Prostatic Cancer.” Tokyo: Kanehara Shuppan (1985).
Gleason D.F., VACURG, Histological grading and clinical staging of prostatic carcinoma, Tannenbaum M., ed., in: “Urologic Pathology: The Prostate,” pp 171–197, Lea and Febiger, Philadelphia (1977).
Mostofi F.K., “Histological Typing of Prostate Tumours,” World Health Organization (1980).
Varkarakis M. J., et al, Lung metastases in prostatic carcinoma, Clinical significance, Urology 3:447–452 (1974).
Rodin A.E., Larson D.L., Roberts D.K., Nature of the perineural space invaded by prostatic carcinoma, Cancer 10:1772–1778 (1967).
Geldof A.A., Rao B.R., Prostatic tumor (R3327) skeletal metastasis, The Prostate 16:279–290 (1990).
Plesnicar S., The course of metastatic disease originating from carcinoma of the prostate, Clin. Exper. Metast. 3:103–110 (1985).
Zeidman I., Buss J.H., Transpulmonary passage of tumor cell emboli, Cancer Res. 12:731–733 (1952).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Harada, M., Iida, Mi., Yamaguchi, M., Shida, K. (1992). Analysis of Bone Metastasis of Prostatic Adenocarcinoma in 137 Autopsy Cases. In: Karr, J.P., Yamanaka, H. (eds) Prostate Cancer and Bone Metastasis. Advances in Experimental Medicine and Biology, vol 324. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3398-6_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3398-6_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6501-3
Online ISBN: 978-1-4615-3398-6
eBook Packages: Springer Book Archive