Abstract
Luminal antigens that have penetrated into the intestinal lamina propria, interact with different components of the immune system including dendritic cells and macrophages. Dendritic cells are potent immunostimulatory cells and can take up and present both intestinally and orally administered antigens to naive T cells1,2. Intestinal macrophages also ingest antigen, but often have an immunosuppressive function: they either inhibit the effect of dendritic cells (mouse3), or have no detectable action (human4). Mucosa-associated macrophages in other systems have similar suppressive effects on immune responses in vitro and in vivo5–7.
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References
Liu, L.M. & MacPherson, G.G. Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens. Immunology 73:281 (1991).
Liu, L.M. & MacPherson, G.G. Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J Exp Med 177:1299 (1993).
Pavli, P., Woodhams, C.E., Doe, W.F. & Hume, DA. Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria. Immunology 70:40 (1990).
Pavli, P., Hume, D.A., van de Pol, E. & Doe, W.F. Dendritic cells, the major antigen-presenting cells of the human colonic lamina propria. Immunology 78:132 (1993).
Holt, P.G., Degebrodt, A., O’Leary, C, Krska, K. & Plozza, T. T cell activation by antigen-presenting cells from lung tissue digests: suppression by endogenous macrophages. Clin Exp Immunol 62:586 (1985).
Thepen, T., van Rooijen, N. & Kraal, G. Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J Exp Med 170:499 (1989).
Spiteri, M.A. & Poulter, L.W. Characterization of immune inducer and suppressor macrophages from the normal human lung. Clin Exp Immunol 83:157 (1991).
Prickett, T.C.R., McKenzie, J.L. & Hart, D.N.J. Characterization of interstitial dendritic cells in human liver. Transplantation, 46:754 (1988).
Betjes, M.G.H., Haks, M.C., Tuk, C.W. & Beelen, R.H.J. Monoclonal antibody EBM11 (anti-CD68) discriminates between dendritic cells and macrophages after short-term culture. Immunobiol 183:79 (1991).
Bujdoso, R., Hopkins, J., Dutia, B.M., Young, P. & McConnell, I. Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage. J Exp Med 170:1285 (1989).
Thepen, T., Hoeben, K., Breve, J. & Kraal, G. Alveolar macrophages down-regulate local pulmonary immune responses against intratracheally administered T-cell-dependent, but not T-cell-independent antigens. Immunology 76:60 (1992).
Holt, P.G., et al. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 177:397 (1993).
Bilyk, N. & Holt, P.G. Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor. J Exp Med 177:1773 (1993).
Shamoto, M., et al. Langerhans cells in the lymph node: mirror section and immunoelectron microscopic studies. Virchows Archiv B 61:337 (1992).
Hume, D.A., Allan, W., Hogan, P.G. & Doe, W.F. Immunohistochemical characterization of macrophages in human liver and gastrointestinal tract: expression of CD4, HLA-DR, OKM1 and the mature macrophage marker, 25F9, in normal and diseased tissue. J Leuk Biol 42:474 (1987).
Hume, DA., Robinson, A.P., MacPherson, G.G. & Gordon, S. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen, F4/80. J Exp Med 158:1522 (1983).
Holt, P.G., Schon-Hegrad, M.A., Phillips, M.J. & McMenamin, P.G. Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium. Clin Exp Allergy 19:597 (1989).
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Pavli, P., Maxwell, L., van de Pol, E., Doe, W.F. (1995). Distribution of Human Colonic Dendritic Cells and Macrophages - Functional Implications. In: Banchereau, J., Schmitt, D. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 378. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1971-3_26
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DOI: https://doi.org/10.1007/978-1-4615-1971-3_26
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