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The Orphanin FQ/Nociceptin (OFQ/N) System

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Orphan G Protein-Coupled Receptors and Novel Neuropeptides

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 46))

Abstract

Orphanin FQ/nociceptin (OFQ/N) was the first novel neuropeptide discovered as the natural ligand of an orphan G protein-coupled receptor (GPCR). Orphan GPCRs are proteins classified as receptors on the basis of their sequence similarities to known GPCRs but that lack the ligands that activate them in vivo. One such orphan GPCR exhibited sequence similarities with the opioid receptors. OFQ/N was isolated as its natural ligand and shown to also share sequence similarities to the opioid peptides. This led to numerous studies attempting to find functional similarities and differences between the OFQ/N and opioid systems. This chapter will summarize our knowledge of the OFQ/N system and of its roles in the organism.

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  1. Department of Pharmacology, Department of Developmental and Cell Biology, University of California, Irvine, Med surge II, Room 369, 92697-4625, Irvine, CA, USA

    Olivier Civelli

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Civelli, O. (2008). The Orphanin FQ/Nociceptin (OFQ/N) System. In: Civelli, O., Zhou, QY. (eds) Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2007_057

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