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Apoptotic Cells at the Crossroads of Tolerance and Immunity

  • Chapter
Role of Apoptosis in Infection

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 289))

Abstract

Clearance of apoptotic cells by phagocytes can result in either anti-inflammatory and immunosuppressive effects or prostimulatory consequences through presentation of cell-associated antigens to T cells. The differences in outcome are due to the conditions under which apoptosis is induced, the type of phagocytic cell, the nature of the receptors involved in apoptotic cell capture, and the milieu in which phagocytosis of apoptotic cells takes place. Preferential ligation of specific receptors on professional antigen-presenting cells dendriticc cells) has been proposed to induce potentially tolerogenic signals. On the other hand, dendritic cells can efficiently process and present antigens from pathogen-infected apoptotic cells to T cells. In this review, we discuss how apoptotic cells manipulate immunity through interactions with dendritic cells.

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Authors and Affiliations

  1. Cancer Institute, NYU School of Medicine, 550 First Avenue, MSB507, New York, NY, 0016, USA

    M. Škoberne, A.-S. Beignon, M. Larsson & N. Bhardwaj

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  1. M. Škoberne
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  2. A.-S. Beignon
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  3. M. Larsson
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  4. N. Bhardwaj
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  1. Bloomberg School of Public Health Department of Molecular Microbiology and Immunology, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD, 21205, USA

    Diane E. Griffin MD, PhD

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© 2005 Springer-Verlag

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Škoberne, M., Beignon, AS., Larsson, M., Bhardwaj, N. (2005). Apoptotic Cells at the Crossroads of Tolerance and Immunity. In: Griffin, D.E. (eds) Role of Apoptosis in Infection. Current Topics in Microbiology and Immunology, vol 289. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27320-4_12

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