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Congenital Malformations of the Spine and Spinal Cord

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Pediatric Neuroradiology

Abstract

Congenital malformations of the spine and spinal cord that most commonly elicit medical examination are represented by spinal dysraphisms and caudal spinal anomalies. Although most of these conditions are diagnosed at birth or in early infancy, some may be discovered in older children or even in adults. Because of its multiplanar imaging and tissue characterization capabilities, magnetic resonance imaging (MRI) has greatly ameliorated the diagnosis of these disorders and has enhanced the possibility of earlier and case-tailored treatment.

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References

  1. Tortori-Donati P, Rossi A, Cama A. Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology 2000;42:471–491.

    Article  CAS  PubMed  Google Scholar 

  2. Auroux M, Haegel P. Organogenése. Système nerveux, organes de sens, intégration neuro-endocrinienne. In: Tuchmann-Duplessis H, ed. Embryologie. Travaux pratiques et enseignement dirigé, 3ème ed. Paris: Masson; 1992.

    Google Scholar 

  3. Bayer SA, Altman J, Russo RJ, Zhang X. Embryology. In: Duckett S, ed. Pediatric Neuropathology. Baltimore: Williams & Wilkins; 1995:54–107.

    Google Scholar 

  4. Dias MS, Walker ML. The embryogenesis of complex dysraphic malformations: a disorder of gastrulation? Pediatr Neurosurg 1992;18:229–253.

    Article  CAS  PubMed  Google Scholar 

  5. Moore KL, ed. The developing human. Clinically oriented embryology, 4th edn. Philadelphia: WB Saunders Co; 1988.

    Google Scholar 

  6. Naidich TP, Blaser SI, Delman BN, McLone DG, Dias MS, Zimmerman RA, Raybaud CA, Birschansky SB, Altman NR, Braffman BH. Embryology of the spine and spinal cord. ASNR Proceedings 2002:3–13.

    Google Scholar 

  7. Nievelstein RAJ, Hartwig NG, Vermeji-Keers C, Valk J. Embryonic development of the mammalian caudal neural tube. Teratology 1993;48:21–31.

    Article  CAS  PubMed  Google Scholar 

  8. Raybaud CA, Naidich TP, McLone DG. Development of the spine and spinal cord. In: Manelfe C, ed. Imaging of the spine and spinal cord. New York: Raven Press; 1992:93–113.

    Google Scholar 

  9. Van Allen MI, Kalousek DK, Chernoff GF, Juriloff D, Harris M, McGillivray BC, Yong SL, Langlois S, MacLeod PM, Chitayat D, Friedman JM, Wilson RD, McFadden D, Pantzar J, Ritchie S, Hall JG. Evidence for multisite closure of the neural tube in humans. Am J Med Genet 1993;47:723–743.

    Article  PubMed  Google Scholar 

  10. O’Rahilly R, Muller F. The two sites of fusion of the neural folds and the two neuropores in the human embryo. Teratology 2002;65:162–170.

    Article  PubMed  CAS  Google Scholar 

  11. Shum AS, Copp AJ. Regional differences in morphogenesis of the neuroepithelium suggest multiple mechanisms of spinal neurulation in the mouse. Anat Embryol (Berl) 1996;194:65–73.

    Article  CAS  PubMed  Google Scholar 

  12. Catala M. Genetic control of caudal development. Clin Genet 2002;61:89–96.

    Article  CAS  PubMed  Google Scholar 

  13. Reimann AF, Anson BJ. Vertebral level of termination of the spinal cord with a report of a case of sacral cord. Anat Rec 1944;88:127–138.

    Article  Google Scholar 

  14. Barson AJ. The vertebral level of termination of the spinal cord during normal and abnormal development. J Anat 1970;106:489–497.

    CAS  PubMed  Google Scholar 

  15. Warder DE. Tethered cord syndrome and occult spinal dysraphism. Neurosurg Focus [serial online]. January 2001; 10: Article 1. Available at http://www.neurosurgery.org/focus/jan01/10-1-1.pdf. Accessed November 20, 2001.

    Google Scholar 

  16. Drolet B. Birthmarks to worry about. Cutaneous markers of dysraphism. Dermatol Clin 1998;16:447–453.

    CAS  PubMed  Google Scholar 

  17. French BN. The embryology of spinal dysraphism. Clin Neurosurg 1983;30:295–340.

    CAS  PubMed  Google Scholar 

  18. Sattar MT, Bannister CM, Turnbull IW. Occult spinal dysraphism — The common combination of lesions and the clinical manifestations in 50 patients. Eur J Pediatr Surg 1996;6(Suppl I):10–14.

    Article  PubMed  Google Scholar 

  19. Tortori-Donati P, Fondelli MP, Rossi A. Anomalie congenite del midollo spinale. In: Simonetti G, Del Maschio A, Bartolozzi C, Passariello R, eds. Trattato Italiano di Risonanza Magnetica. Naples: Idelson-Gnocchi; 1998:517–553.

    Google Scholar 

  20. Warder DE, Oakes WJ. Tethered cord syndrome and the conus in a normal position. Neurosurgery 1993;33:374–378.

    Article  CAS  PubMed  Google Scholar 

  21. Warder DE, Oakes WJ. Tethered cord syndrome: the lowlying and normally positioned conus. Neurosurgery 1994;34:597–600.

    Article  CAS  PubMed  Google Scholar 

  22. Herman JM, McLone DG, Storrs BB, Dauser RC. Analysis of 153 patients with myelomeningocele or spinal lipoma reoperated upon for a tethered cord. Pediatr Neurosurg 1993; 19:243–249.

    Article  CAS  PubMed  Google Scholar 

  23. McLone DG, Dias MS. Complications of myelomeningocele closure. Pediatr Neurosurg 1991–92;17:267–273.

    Article  PubMed  Google Scholar 

  24. Tortori-Donati P, Cama A, Rosa ML, Andreussi L, Taccone A. Occult spinal dysraphism: neuroradiological study. Neuroradiology 1990;31:512–522.

    Article  CAS  PubMed  Google Scholar 

  25. Raghavan N, Barkovich AJ, Edwards M, Norman D. MR imaging in the tethered spinal cord syndrome. AJNR Am J Neuroradiol 1989;10:27–36.

    Google Scholar 

  26. Long FR, Hunter JV, Mahboubi S, Kalmus A, Templeton JM. Tethered cord and associated vertebral anomalies in children and infants with imperforate anus: evaluation with MR imaging and plain radiography. Radiology 1996;200:377–382.

    CAS  PubMed  Google Scholar 

  27. Scott RM, Wolpert SM, Bartoshesky LF, Zimbler S, Klauber GT. Dermoid tumors occurring at the site of previous myelomeningocele repair. J Neurosurg 1986;65:779–783.

    Article  CAS  PubMed  Google Scholar 

  28. Schneider SJ, Rosenthal AD, Greenberg BM, Danto J. A preliminary report on the use of laser Doppler flowmetry during tethered cord release. Neurosurgery 1993;32:214–217.

    Article  CAS  PubMed  Google Scholar 

  29. Pang D, Dias MS, Ahab-Barmada M. Split cord malformation. Part I: a unified theory of embryogenesis for double spinal cord malformations. Neurosurgery 1992;31:451–480.

    CAS  PubMed  Google Scholar 

  30. Pang D. Split cord malformation. Part II: clinical syndrome. Neurosurgery 1992;31:481–500.

    Article  CAS  PubMed  Google Scholar 

  31. Cama A, Tortori-Donati P, Piatelli GL, Fondelli MP, Andreussi L. Chiari complex in children. Neuroradiological diagnosis, neurosurgical treatment and proposal of a new classification (312 cases). Eur J Pediatr Surg 1995;5(Suppl 1):35–38.

    Article  PubMed  Google Scholar 

  32. Tortori-Donati P, Cama A, Fondelli MP, Rossi A. Le malformazioni di Chiari. In: Tortori-Donati P, Taccone A, Longo M, eds. Malformazioni cranio-encefaliche. Neuroradiologia. Turin: Minerva Medica; 1996:209–236.

    Google Scholar 

  33. Smithells RW, Sheppard S, Schorah CJ, Seller MJ, Nevin NC, Harris R, Read AP, Fielding DW. Possible prevention of neural tube defects by periconceptional vitamin supplementation. Lancet 1980;1:339–340.

    Article  CAS  PubMed  Google Scholar 

  34. Sutton LN, Adzick NS, Bilaniuk LT, Johnson MP, Crombleholme TM, Flake AW. Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele. JAMA 1999;282:1826–1831.

    Article  CAS  PubMed  Google Scholar 

  35. McLone DG, Knepper PA. Role of complex carbohydrates and neurulation. Pediatr Neurosci 1985–86;12:2–9.

    Article  PubMed  Google Scholar 

  36. Pang D, Dias MS. Cervical myelomeningoceles. Neurosurgery 1993;33:363–373.

    Article  CAS  PubMed  Google Scholar 

  37. Breningstall GN, Marker SM, Tubman DE. Hydrosyringomyelia and diastematomyelia detected by MRI in myelomeningocele. Pediatr Neurol 1992;8:267–271.

    Article  CAS  PubMed  Google Scholar 

  38. McLone DG, Knepper PA. The cause of Chiari II malformation: a unified theory. Pediatr Neurosci 1989;15:1–12.

    Article  CAS  PubMed  Google Scholar 

  39. Naidich TP, McLone DG, Fulling F. The Chiari II malformation. Part IV. The hindbrain deformity. Neuroradiology 1983;25:179–197.

    Article  CAS  PubMed  Google Scholar 

  40. Naidich TP, McLone DG, Mutleur S. A new understanding of dorsal dysraphism with lipoma (lipomyeloschisis): radiological evaluation and surgical correction. AJNR Am J Neuroradiol 1983;4:103–116.

    Google Scholar 

  41. Blount JP, Elton S. Spinal lipomas. Neurosurg Focus [serial online]. January 2001; 10:Article 3. Available at: http://www.neurosurgery.org/focus/jan01/10-1-3.pdf. Accessed November 20, 2001.

    Google Scholar 

  42. Koen JL, McLendon RE, George TM. Intradural spinal teratoma: evidence for a dysembryogenic origin. Report of four cases. J Neurosurg 1998;89:844–851.

    Article  CAS  PubMed  Google Scholar 

  43. Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, Brunelle F, Le Merrer M, Giudicelli Y, Pichon J, Kleinknecht B, Nataf F. Congenital lumbosacral lipomas. Childs Nerv Syst 1997;13:298–334.

    Article  CAS  PubMed  Google Scholar 

  44. Knittle JL, Timmers K, Ginsberg-Fellner F, Brown RE, Katz DP. The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size. J Clin Invest 1979;63:269–246.

    Article  Google Scholar 

  45. Catala M. Embryogenesis. Why do we need a new explanation for the emergence of spina bifida with lipoma? Childs Nerv Syst 1997;13:336–340.

    Article  CAS  PubMed  Google Scholar 

  46. Chapman PH. Congenital intraspinal lipomas: anatomic considerations and surgical treatment. Childs Brain 1982;9:37–47.

    CAS  PubMed  Google Scholar 

  47. Raimondi AJ. Hamartomas and the dysraphic state. In: Raimondi AJ, Choux M, Di Rocco C, eds. The pediatric spine I. Development and the dysraphic state. Berlin: Springer; 1989:179–199.

    Google Scholar 

  48. Lee KS, Gower DJ, McWhorter JM, Albertson DA. The role of MR imaging in the diagnosis and treatment of anterior sacral meningocele. Report of 2 cases. J Neurosurg 1988;69:628–631.

    Article  CAS  PubMed  Google Scholar 

  49. Castillo M, Mukherji SK. Imaging of the pediatric head, neck, and spine. Philadelphia: Lippincott-Raven; 1996:638–640.

    Google Scholar 

  50. Okada T, Imae S, Igarashi S, Koyama T, Yamashita J. Occult intrasacral meningocele associated with spina bifida: a case report. Surg Neurol 1996;46:147–149.

    Article  CAS  PubMed  Google Scholar 

  51. Byrd SE, Harvey C, Darling CF. MR of terminal myelocystoceles. Eur J Radiol 1995;20:215–220.

    Article  CAS  PubMed  Google Scholar 

  52. McLone DG, Naidich TP. Terminal myelocystocele. Neurosurgery 1985;16:36–43.

    Article  CAS  PubMed  Google Scholar 

  53. Peacock WJ, Murovic JA. Magnetic resonance imaging in myelocystoceles. Report of two cases. J Neurosurg 1989;70:804–807.

    Article  CAS  PubMed  Google Scholar 

  54. Carey JC, Greenbaum B, Hall BD. The OEIS complex (omphalocele, exstrophy, imperforate anus, spinal defects). Birth Defects Orig Artic Ser 1978;14:253–263.

    CAS  PubMed  Google Scholar 

  55. Smith NM, Chambers HM, Furness ME, Haan EA. The OEIS complex omphalocele-exstrophy-imperforate anus-spinal defects: recurrence in sibs. J Med Genet 1992;29:730–732.

    Article  CAS  PubMed  Google Scholar 

  56. Nishino A, Shirane R, So K, Arai H, Suzuki H, Sakurai Y. Cervical myelocystocele with Chiari II malformation: magnetic resonance imaging and surgical treatment. Surg Neurol 1998;49:269–273.

    Article  CAS  PubMed  Google Scholar 

  57. Altman NR, Altman DH. MR imaging of spinal dysraphism. AJNR Am J Neuroradiol 1987;8:533–538.

    CAS  PubMed  Google Scholar 

  58. Hendrick EB, Hoffman HJ, Humphreys RP. The tethered spinal cord. Clin Neurosurg 1983;30:457–463.

    CAS  PubMed  Google Scholar 

  59. Hansasuta A, Tubbs RS, Oakes WJ. Filum terminale fusion and dural sac termination: study in 27 cadavers. Pediatr Neurosurg 1999;30:176–179.

    Article  CAS  PubMed  Google Scholar 

  60. Brown E, Matthes JC, Bazan C 3rd, Jinkins JR. Prevalence of incidental intraspinal lipoma of the lumbosacral spine as determined by MRI. Spine 1994;19:833–836.

    Article  CAS  PubMed  Google Scholar 

  61. Uchino A, Mori T, Ohno M. Thickened fatty filum terminale: MR imaging. Neuroradiology 1991;33:331–333.

    Article  CAS  PubMed  Google Scholar 

  62. Yundt KD, Park TS, Kaufman BA. Normal diameter of filum terminale in children: in vivo measurement. Pediatr Neurosurg 1997;27:257–259.

    Article  CAS  PubMed  Google Scholar 

  63. Scotti G, Harwood-Nash DC. Congenital thoracic dermal sinus: diagnosis by computer assisted metrizamide myelography. J Comput Assist Tomogr 1980;4:675–677.

    Article  CAS  PubMed  Google Scholar 

  64. Barkovich AJ, Edwards MSB, Cogen PH. MR evaluation of spinal dermal sinus tracts in children. AJNR Am J Neuroradiol 1991;12:123–129.

    CAS  PubMed  Google Scholar 

  65. Weprin BE, Oakes WJ. Coccygeal pits. Pediatrics 2000;105:E69.

    Article  CAS  PubMed  Google Scholar 

  66. Elton S, Oakes WJ. Dermal sinus tracts of the spine. Neurosurg Focus [serial online]. January 2001; 10:Article 4. Available at: http://www.neurosurgery.org/focus/jan01/10-1-4.pdf. Accessed November 20, 2001.

    Google Scholar 

  67. Kernohan JW. The ventriculus terminalis: its growth and development. J Comp Neurol 1924;38:10–125.

    Article  Google Scholar 

  68. Coleman LT, Zimmerman RA, Rorke LB. Ventriculus terminalis of the conus medullaris: MR findings in children. AJNR Am J Neuroradiol 1995;16:1421–1426.

    CAS  PubMed  Google Scholar 

  69. Sigal R, Denys A, Halimi P, Shapeero L, Doyon D, Boudghène F. Ventriculus terminalis of the conus medullaris: MR imaging in four patients with congenital dilatation. AJNR Am J Neuroradiol 1991;12:733–737.

    CAS  PubMed  Google Scholar 

  70. Pang D. Ventral tethering in split cord malformation. Neurosurg Focus [serial online]. January 2001; 10:Article 6. Available at: http://www.neurosurgery.org/focus/jan01/10-1-6.pdf. Accessed November 20, 2001.

    Google Scholar 

  71. Prop N, Frensdorf EL. A postvertebral endodermal cyst associated with axial deformities: a case showing the “endodermal-ectodermal adhesion syndrome”. Pediatrics 1967;39:555–562

    CAS  PubMed  Google Scholar 

  72. Faris JC, Crowe JE. The split notochord syndrome. J Pediatr Surg 1975;10:467–472.

    Article  CAS  PubMed  Google Scholar 

  73. Hoffman CH, Dietrich RB, Pais MJ, Demos DS, Pribham HFW. The split notochord syndrome with dorsal enteric fistula. AJNR Am J Neuroradiol 1993;14:622–627.

    CAS  PubMed  Google Scholar 

  74. Castillo M, Hankins L, Kramer L, Wilson BA. MR imaging of diplomyelia: case report. Magn Reson Imaging 1992;10:699v703.

    Google Scholar 

  75. Brooks BS, Duvall ER, El Gammal T, Garcia JH, Gupta KL, Kapila A. Neuroimaging features of neurenteric cysts: analysis of nine cases and review of the literature. AJNR Am J Neuroradiol 1993;14:735–746.

    CAS  PubMed  Google Scholar 

  76. Gao P, Osborn AG, Smirniotopoulos JG, Palmer CA, Boyer RS. Neurenteric cysts. Pathology, imaging spectrum, and differential diagnosis. Int J Neuroradiol 1995;1:17–27.

    Google Scholar 

  77. Wilkins RH, Odum GL. Spinal intradural cysts. In: Vinken PJ, Bruyn GW, eds. Handbook of Clinical Neurology, vol. 20. Amsterdam: North Holland; 1976:55–102.

    Google Scholar 

  78. Kincaid PK, Stanley P, Kovanlikaya A, Mahour GH, Rowland JM. Coexistent neurenteric cyst and enterogenous cyst. Further support for a common embryologic error. Pediatr Radiol 1999;29:539–541.

    Article  CAS  PubMed  Google Scholar 

  79. Paleologos TS, Thom M, Thoms DG. Spinal neurenteric cysts without associated malformations. Are they the same as those presenting in spinal dysraphism? Br J Neurosurg 2000;14:185–194.

    Article  CAS  PubMed  Google Scholar 

  80. Kadhim H, Proano PG, Saint Martin C, Boscherini D, Clapuyt P, Godfraind C, Duprez T, Raftopoulos C, Sebire G. Spinal neurenteric cyst presenting in infancy with chronic fever and acute myelopathy. Neurology 2000;54:2011–2015.

    CAS  PubMed  Google Scholar 

  81. Rauzzino MJ, Tubbs RS, Alexander E, Grabb PA, Oakes WJ. Spinal neurenteric cysts and their relation to more common aspects of occult spinal dysraphism Neurosurg Focus [serial online]. January 2001; 10:Article 2. Available at: http://www.neurosurgery.org/focus/jan01/10-1-2.pdf. Accessed November 20, 2001.

    Google Scholar 

  82. McLone DG. Occult dysraphism and the tethered spinal cord lipomas. In: Choux M, Di Rocco C, Hockley A (eds) Pediatric Neurosurgery. Philadelphia: Churchill Livingstone; 1999:61–78.

    Google Scholar 

  83. Naidich TP, Harwood-Nash DC. Diastematomyelia. Part I. Hemicords and meningeal sheaths. Single and double arachnoid and dural tubes. AJNR Am J Neuroradiol 1983;4:633–636.

    CAS  PubMed  Google Scholar 

  84. Schlesinger AE, Naidich TP, Quencer RM. Concurrent hydromyelia and diastematomyelia. AJNR Am J Neuroradiol 1986;7:473–477.

    CAS  PubMed  Google Scholar 

  85. Kaffenberger DA, Heinz ER, Oakes JW, Boyko O. Meningocele manquè: radiologic findings with clinical correlation. AJNR Am J Neuroradiol 1992;13:1083–1088.

    CAS  PubMed  Google Scholar 

  86. van Straaten HWM, Hekking JWM. Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo. Anat Embryol (Berl) 1991;184:55–63.

    Article  PubMed  Google Scholar 

  87. Le Douarin NM, Halpern ME. Origin and specification of the neural tube floor plate: insights from the chick and zebrafish. Curr Opin Neurobiol 2000;10:23–30.

    Article  PubMed  Google Scholar 

  88. Wyllie AH. Apoptosis: cell death in tissue regulation. J Pathol 1987;153:313–316.

    Article  CAS  PubMed  Google Scholar 

  89. Maden M, Graham A, Gale E, Rollinson C, Zile M. Positional apoptosis during vertebrate CNS development in the absence of endogenous retinoids. Development 1997;124:2799–2805.

    CAS  PubMed  Google Scholar 

  90. Tortori-Donati P, Fondelli MP, Rossi A, Raybaud CA, Cama A, Capra V. Segmental spinal dysgenesis. Neuroradiologic findings with clinical and embryologic correlation. AJNR Am J Neuroradiol 1999;20:445–456.

    CAS  PubMed  Google Scholar 

  91. Duhamel B. From the mermaid to anal imperforation: the syndrome of caudal regression. Arch Dis Child 1961;36:152–155.

    Article  Google Scholar 

  92. Valenzano M, Paoletti R, Rossi A, Farinini D, Garlaschi G, Fulcheri E. Sirenomelia. Pathological features, antenatal ultrasonographic clues, and a review of current embryogenic theories. Hum Reprod Update 1999;5:82–86.

    Article  CAS  PubMed  Google Scholar 

  93. Raffel C, Litofsky S, McComb JG. Central nervous system malformations and the VATER association. Pediatr Neurosurg 1990–91;16:170–173.

    Article  PubMed  Google Scholar 

  94. Currarino G, Coln D, Votteler T. Triad of anorectal, sacral, and presacral anomalies. AJR Am J Roentgenol 1981;137:395–398.

    CAS  PubMed  Google Scholar 

  95. Dias MS, Azizkhan RG. A novel embryogenetic mechanism for Currarino’s triad: inadequate dorsoventral separation of the caudal eminence from hindgut endoderm. Pediatr Neurosurg 1998;28:223–229.

    Article  CAS  PubMed  Google Scholar 

  96. Gudinchet F, Maeder P, Laurent T, Meyrat B, Schnyder P. Magnetic resonance detection of myelodysplasia in children with Currarino triad. Pediatr Radiol 1997;27:903–907.

    Article  CAS  PubMed  Google Scholar 

  97. Pang D. Sacral agenesis and caudal spinal cord malformations. Neurosurgery 1993;32:755–779.

    Article  CAS  PubMed  Google Scholar 

  98. Nievelstein RAJ, Valk J, Smit LME, Vermeji-Keers C. MR of the caudal regression syndrome: embryologic implications. AJNR Am J Neuroradiol 1994;15:1021–1029.

    CAS  PubMed  Google Scholar 

  99. Barkovich AJ, Raghavan N, Chuang SH. MR of lumbosacral agenesis. AJNR Am J Neuroradiol 1989;10:1223–1231.

    CAS  PubMed  Google Scholar 

  100. Sherman JL, Barkovich AJ, Citrin CM. The MR appearance of syringomyelia: new observations. AJNR Am J Neuroradiol 1986;7:985–995.

    Google Scholar 

  101. Williams B. The distending force in the production of “communicating syringomyelia”. Lancet 1969;2:189–193

    Article  CAS  PubMed  Google Scholar 

  102. Aubin ML, Vignaud J, Jardin Bar D. Computed tomography in 75 clinical cases of syringomyelia. AJNR Am J Neuroradiol 1981;2:199–204.

    CAS  PubMed  Google Scholar 

  103. Greitz D, Ericson K, Flodmark O. Pathogenesis and mechanisms of spinal cord cysts: a new hypothesis based on magnetic resonance studies of cerebro spinal fluid dynamics. Int J Neuroradiol 1999;5:61–78.

    Google Scholar 

  104. Milhorat TH, Capocelli AL, Anzil AP, Kotzen RM, Milhorat RH. Pathological basis of spinal cord cavitation in syringomyelia: analysis of 105 autopsy cases. J Neurosurg 1995;82:802–812.

    Article  CAS  PubMed  Google Scholar 

  105. Da Costa Machado MA, Matos de Souza PE, De Sousa Matos H, Barbosa VA, Bastos CA, Vieira LC. Syringomyelia. Imaging findings and review of the pathogenesis in 28 cases. Int J Neuroradiol 1999;5:285–291.

    Google Scholar 

  106. Jinkins JR, Reddy S, Leite CC, Bazan C 3rd, Xiong L. MR of parenchymal spinal cord signal change as a sign of active advancement in clinically progressive posttraumatic syringomyelia. AJNR Am J Neuroradiol 1998;19:177–182.

    CAS  PubMed  Google Scholar 

  107. Fischbein NJ, Dillon WP, Cobbs C, Weinstein PR. The “presyrinx state”: a reversible myelopathic condition that may precede syringomyelia. AJNR Am J Neuroradiol 1999;20:7–20

    CAS  PubMed  Google Scholar 

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Tortori-Donati, P., Rossi, A., Biancheri, R., Cama, A. (2005). Congenital Malformations of the Spine and Spinal Cord. In: Pediatric Neuroradiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26398-5_39

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