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Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats

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Intracranial Pressure and Brain Monitoring XII

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 95))

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References

  1. Baskaya MK, Rao AM, Donaldson D, Prasad MR, Dempsey RJ (1997) Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formation in focal cerebral ischemia. Neurosurgery 40: 364–370

    Article  PubMed  CAS  Google Scholar 

  2. Brindley PG, Markland DM, Mayers I, Kutsogiannis DJ (2002) Predictors of survival following in-hospital adult cardiopulmonary resuscitation. CMAJ 167: 343–348

    PubMed  Google Scholar 

  3. Bunch TJ, White RD, Gersh BJ, Meverden RA, Hodge DO, Ballman KV, Hammill SC, Shen WK, Packer DL (2003) Longterm outcomes of out-of-hospital cardiac arrest after successful early defibrillation. N Engl J Med 348: 2626–2633

    Article  PubMed  Google Scholar 

  4. Bunch TJ, White RD, Khan AH, Packer DL (2004) Impact of age on long-term survival and quality of life following out-of-hospital cardiac arrest. Crit Care Med 32: 963–967

    Article  PubMed  Google Scholar 

  5. Clasen RA, Huckman MS, Von Roenn KA, Pandolfi S, Laing I, Lobick JJ (1981) A correlative study of computed tomography and histology in human and experimental vasogenic cerebral edema. J Comput Assist Tomogr 5: 313–327

    PubMed  CAS  Google Scholar 

  6. Dogan A, Rao AM, Baskaya MK, Rao VL, Rastl J, Donaldson D, Dempsey RJ (1997) Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. J Neurosurg 87: 921–926

    Article  PubMed  CAS  Google Scholar 

  7. Dolinak D, Smith C, Graham DI (2000) Global hypoxia per se is an unusual cause of axonal injury. Acta Neuropathol (Berl) 100: 553–560

    Article  PubMed  CAS  Google Scholar 

  8. Fujioka M, Okuchi K, Sakaki T, Hiramatsu K, Miyamoto S, Iwasaki S (1994) Specific changes in human brain following reperfusion after cardiac arrest. Stroke 25: 2091–2095

    PubMed  CAS  Google Scholar 

  9. Gillum RF (1989) Sudden coronary death in the United States: 1980–1985. Circulation 79: 756–765

    PubMed  CAS  Google Scholar 

  10. Gotti B, Duverger D, Bertin J, Carter C, Dupont R, Frost J, et al (1988) Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. J Pharmacol Exp Ther 247: 1211–1221

    PubMed  CAS  Google Scholar 

  11. Han Z, Wax MB, Patil RV (1998) Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation. J Biol Chem 273: 6001–6004

    Article  PubMed  CAS  Google Scholar 

  12. Hardingham GE, Chawla S, Cruzalegui FH, Bading H (1999) Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and Ltype calcium channels. Neuron 22: 789–798

    Article  PubMed  CAS  Google Scholar 

  13. Hu BR, Fux CM, Martone ME, Zivin JA, Ellisman MH (1999) Persistent phosphorylation of cyclic AMP responsive elementbinding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain. Neuroscience 89: 437–452

    Article  PubMed  CAS  Google Scholar 

  14. Kelsen J, Obel A (2003) Fatal cerebral hypoxemia after cardiac arrest. NEJM 348: 817

    Article  PubMed  Google Scholar 

  15. Koenig H, Trout JJ, Goldstone AD, Lu CY (1992) Capillary NMDA receptors regulate blood-brain barrier function and breakdown. Brain Res 588: 297–303

    Article  PubMed  CAS  Google Scholar 

  16. Krizbai IA, Deli MA, Pestenacz A, Siklos L, Szabo CA, Andras I, Joo F (1998) Expression of glutamate receptors on cultured cerebral endothelial cells. J Neurosci Res 54: 814–819

    Article  PubMed  CAS  Google Scholar 

  17. Laake JH, Haug FM, Wieloch T, Ottersen OP (1999) A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence. Brain Res Brain Res Protoc 4: 173–184

    Article  PubMed  CAS  Google Scholar 

  18. Longstreth WT Jr, Inui TS, Cobb LA, Copass MK (1983) Neurologic recovery after out-of-hospital cardiac arrest. Ann Intern Med 985: 588–592

    Google Scholar 

  19. Mabuchi T, Kitagawa K, Kuwabara K, Takasawa K, Ohtsuki T, Xia Z, Storm D, Yanagihara T, Hori M, Matsumoto M (2001) Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. J Neurosci 21: 9204–9213

    PubMed  CAS  Google Scholar 

  20. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS (2000) Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med 6: 159–163

    Article  PubMed  CAS  Google Scholar 

  21. Morimoto Y, Kemmotsu O, Kitami K, Matsubara I, Tedo I (1993) Acute brain swelling after out-of-hospital cardiac arrest: pathogenesis and outcome. Crit Care Med 21: 104–110

    Article  PubMed  CAS  Google Scholar 

  22. Nakahama K, Nagano M, Fujioka A, Shinoda K, Sasaki H (1999) Effect of TPA on aquaporin 4 mRNA expression in cultured rat astrocytes. Glia 25: 240–246

    Article  PubMed  CAS  Google Scholar 

  23. National Center for Health Statistics (1995) Advance report of final mortality statistics, 1995. Monthly Vital Statistics Report. 45: 82

    Google Scholar 

  24. Nellgard B, Wieloch T (1992) Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia. J Cereb Blood Flow Metab 12: 2–11

    PubMed  CAS  Google Scholar 

  25. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP (1997) Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17: 171–180

    PubMed  CAS  Google Scholar 

  26. Rosenberg GA (1999) Ischemic brain edema. Prog Cardiovasc Dis 42: 209–216

    Article  PubMed  CAS  Google Scholar 

  27. Sala C, Rudolph-Correia S, Sheng M (2000) Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocampal neurons. J Neurosci 20: 3529–3536

    PubMed  CAS  Google Scholar 

  28. Takano K, Tatlisumak T, Formato JE, Carano RA, Bergmann AG, Pullan LM, Bare TM, Sotak CH, Fisher M (1997) Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke 28:1255–1262

    PubMed  CAS  Google Scholar 

  29. Taniguchi M, Yamashita T, Kumura E, Tamatani M, Kobayashi A, Yokawa T, Maruno M, Kato A, Ohnishi T, Tohyama M, Yoshimine T (2000) Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat. Brain Res Mol Brain Res 78: 131–137

    Article  PubMed  CAS  Google Scholar 

  30. van Alem AP, Waalewijn RA, Koster RW, de Vos R (2004) Assessment of quality of life and cognitive function after out-of-hospital cardiac arrest with successful resuscitation. Am J Cardiol 93: 131–135

    Article  PubMed  Google Scholar 

  31. Venero JL, Vizuete ML, Machado A, Cano J (2001) Aquaporins in the central nervous system. Prog Neurobiol 63: 321–336

    Article  PubMed  CAS  Google Scholar 

  32. Xiao F (2002) Bench to bedside: brain edema and cerebral resuscitation: the present and future. Acad Emerg Med 9: 933–946

    Article  PubMed  Google Scholar 

  33. Xiao F, Rodrignez J, Arnold TC, Zhang S. Ferrara D, Ewing J, Alexander JS, Carden DL, Conrad SA (2004) Near-infrared spectroscopy: a tool to monitor cerebral hemodynamic and metabolic changes after cardiac arrest in rats. Resuscitation 63:213–220

    Article  PubMed  CAS  Google Scholar 

  34. Xiao F, Pardue S, Arnold T, Carden D, Alexander JS, Monroe J, Sharp CD, Turnage R, Conrad S (2004) Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. Resuscitation 61: 209–219

    Article  PubMed  CAS  Google Scholar 

  35. Xiao F, Zhang Z, Arnold TC, Alexander1 JS, Huang J, Carden DL, Conrad SA (2002) Mild hypothermia induced before cardiac arrest reduces brain edema formation in rats. Academic Emerg Med 9: 105–114

    Article  Google Scholar 

  36. Xiao F, Arnold TC, Zhang S, Brown C, Alexander JS, Carden DL, Conrad SA (2004) Cerebral cortical aquaporin-4 expression in brain edema following cardiac arrests in rats. Academic Emerg Med 11: 1001–1007

    Article  Google Scholar 

  37. Young KD, Gausche-Hill M, McClung CD, Lewis RJ (2004) A prospective, population-based study of the epidemiology and outcome of out-of-hospital pediatric cardiopulmonary arrest. Pediatrics 114: 157–164

    Article  PubMed  Google Scholar 

  38. Young KD, Keidel JS (1999) Pediatric cardiopulmonary resuscitation: a collective review. Ann Emerg Med 33: 195–205

    Article  PubMed  CAS  Google Scholar 

  39. Zheng ZJ, Croft JB, Giles WH, Mensah GA (2001) Sudden cardiac death in the United States, 1989 to 1998. Circulation 104:2158–2163

    PubMed  CAS  Google Scholar 

  40. Zheng ZJ, Croft JB, Giles WH (2002) MMWR 51(06): 123–126

    Google Scholar 

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Xiao, F. et al. (2005). Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats. In: Poon, W.S., et al. Intracranial Pressure and Brain Monitoring XII. Acta Neurochirurgica Supplementum, vol 95. Springer, Vienna. https://doi.org/10.1007/3-211-32318-X_85

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  • DOI: https://doi.org/10.1007/3-211-32318-X_85

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-24336-7

  • Online ISBN: 978-3-211-32318-2

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