Conclusion
Collagen type I inhibits the co-stimulatory activity of DPPIV/CD26, and hence modulates the T cell activation. The enzymatic activity of DPPIV is not necessary for the co-stimulatory activity of this molecule in T cell activation. DPPIV/CD26 plays an important role in the development, maturation, activation and differentiation of T cells as well as on their functions in the immune system. Deficiency of DPPIV/CD26 results in an impaired development and maturation of CD4 lymphocytes and a disturbed response to PWM stimulation. The IL-4 secretion was decreased, and hence the IgG production was reduced and isotype switching to IgE was affected.
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Fan, H., Yan, S., Stehling, S., Marguet, D., Schuppan, D., Reutter, W. (2004). Dipeptidyl Peptidase IV/CD26 in T Cell Activation, Cytokine Secretion and Immunoglobulin Production. In: Back, N., Cohen, I.R., Kritchevsky, D., Lajtha, A., Paoletti, R. (eds) Dipeptidyl Aminopeptidases in Health and Disease. Advances in Experimental Medicine and Biology, vol 524. Springer, Boston, MA. https://doi.org/10.1007/0-306-47920-6_20
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