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The association between cumulative C-reactive protein and brachial–ankle pulse wave velocity

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Abstract

Background and aims

This study aimed to investigate the association between cumulative C-reactive protein (cumCPR) and arterial stiffness.

Methods

The cross-sectional study included 15,432 participants from the Kailuan Cohort. The participants were divided into four groups according to cumCRP quartiles. The average brachial–ankle pulse wave velocity (baPWV) and detective rate of increased arterial stiffness were compared between exposure groups. Statistical analysis was performed with multiple logistic regression analysis to estimate the association between cumCRP and arterial stiffness by calculating the odds ratios (ORs) and 95% confidence intervals (CIs). The several sensitivity analyses were performed to test the robustness of our findings.

Results

The average baPWV increased from 1425.70 cm/s of Q1 group to 1626.48 cm/s of Q4 group. And the detective rate of arterial stiffness increased from 44.7 to 70.1% (P < 0.001). Multiple logistic regression analysis showed that after adjusting the confounding factors, compared to the Q1 group, the Q4 group had 42% (adjusted OR 1.42; 95% CI 1.24–1.63) higher arterial stiffness risk. In addition, 10% (adjusted OR 1.10; 95% CI 1.02–1.18) arterial stiffness risk was increased per 1 standard deviation (SD) of cumCRP after a fully adjusted regression model.

Conclusion

Higher cumCRP exposure is associated with increased arterial stiffness.

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Acknowledgments

This study was supported by the Group Company of Chinese Kailuan. The contributions of the general practitioners of the Kailuan Study are also gratefully acknowledged.

Funding

None.

Author information

Authors and Affiliations

  1. Department of Emergency, Affiliated Hospital, North China University of Science and Technology, No. 73 Jianshe South Road, Lubei District, Tangshan, 063000, China

    Lixia Sun, Tao Yao, Li Zhang, Lei Zhao, Xiaoxuan Wei, Xiaoling Zhang & Yang Gao

  2. Department of Emergency, The Third People’s Hospital of Hubei Province, Wuhan, China

    Chunhong Ning

  3. Department of ICU, Lishui Overseas Chinese Hospital, Lishui, China

    Jiqiang Liu

  4. Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, No. 57 Xinhua Road, Lubei District, Tangshan, 063000, China

    Ruiying Zhang & Shouling Wu

Authors
  1. Lixia Sun
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  2. Chunhong Ning
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  3. Jiqiang Liu
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  4. Tao Yao
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  5. Li Zhang
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  6. Lei Zhao
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  7. Xiaoxuan Wei
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  8. Xiaoling Zhang
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  9. Yang Gao
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  10. Ruiying Zhang
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  11. Shouling Wu
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Contributions

CN, JL, LS, and SW designed and initiated the study. CN, TY, LZ, LZ, and XZ assisted in data collection. CN, YG, and XW performed the statistical analysis. CN and LS wrote the first draft of the article. All authors made critical comments on the manuscript and took part in interpretation of the results. RZ, LS, and SW supervised the study.

Corresponding authors

Correspondence to Lixia Sun or Shouling Wu.

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Conflict of interest

The authors declared that there is no duality of interest associated with this manuscript.

Ethical approval

This study was approved by the Ethics Committee of the Kailuan Medical Group, Kailuan Company, Tangshan, Hebei Province. Research has been conducted in accordance with the Declaration of Helsinki and its later amendments.

Statement of human and animal rights

This article does not contain any studies with animals performed by any of the authors.

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Written informed consent was obtained from all the participants of this study.

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Cite this article

Sun, L., Ning, C., Liu, J. et al. The association between cumulative C-reactive protein and brachial–ankle pulse wave velocity. Aging Clin Exp Res 32, 789–796 (2020). https://doi.org/10.1007/s40520-019-01274-8

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  • DOI: https://doi.org/10.1007/s40520-019-01274-8

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