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Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies

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Abstract

Apolipoprotein B plays a central role in lipoprotein metabolism. Many studies have evaluated the association between Apolipoprotein B gene polymorphisms (XbaI, EcoRI, SpIns/Del, MspI) and the risk for coronary artery disease and myocardial infarction. However, the results remain inconsistent, particularly among different populations. To more precisely determine the association between Apolipoprotein B gene polymorphisms and coronary artery disease/myocardial infarction risk, we performed a meta-analysis via a comprehensive search of electronic databases (up to February 1st, 2015), odds ratios (OR) and 95 % confidence intervals were calculated using a fixed or random effect model. A total of 47 studies, with 9411 coronary artery disease/myocardial infarction cases and 9082 controls, were included in this meta-analysis. The combined results revealed significant associations between an increased risk of coronary artery disease/myocardial infarction and EcoRI (AA vs GG: OR 1.511, 95 % confidence interval (CI) 1.098, 2.078) and SpIns/Del (DD vs II: OR 1.331, 95 % CI 1.064, 1.665) alleles in the general population. In a subgroup analysis stratified by ethnicity, the T allele of the XbaI variant was associated with a decreased risk in Caucasians, whereas it was associated with an increased risk among the East Asian population. No significant correlation was detected between the A allele of the MspI variant and the coronary artery disease/myocardial infarction risk in either the general population or any ethnic subgroup. The results of our study suggest that Apolipoprotein B gene polymorphisms may affect the coronary artery disease/myocardial infarction susceptibility and these effects may display notable discrepancies among different populations.

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Acknowledgments

We gratefully acknowledge Naping Tang for his assistance in proof-reading in this manuscript. This work is supported by grants from the National High-tech Research and Development Program of China (2012AA02A510, Beijing, China) and the Chinese National Nature Science Foundation (Grant No. 81370219, Beijing, China).

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The authors declare that they have no conflict interests.

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Authors and Affiliations

  1. Department of Cardiology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China

    Dan Xiao, Kaisen Huang, Qingyong Chen, Baotao Huang, Wei Liu, Yong Peng, Mao Chen, Dejia Huang & Jiefu Yang

  2. Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Dan Xiao

  3. Department of Cardiology, Beijing Hospital, Beijing University, Beijing, 100730, People’s Republic of China

    Tong Zou & Jiefu Yang

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  1. Dan Xiao
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Xiao, D., Huang, K., Chen, Q. et al. Four Apolipoprotein B gene polymorphisms and the risk for coronary artery disease: a meta-analysis of 47 studies. Genes Genom 37, 621–632 (2015). https://doi.org/10.1007/s13258-015-0292-3

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