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Effects of MTNR1B variants on fasting glucose levels in a Korean population

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Abstract

Fasting glucose level is the most basic and widely used indicator of diabetes. Several genome wide association studies have reported that the gene encoding melatonin receptor 1B (MTNR1B) exerts a major effect on serum fasting glucose levels. We tested for the association between single nucleotide polymorphisms (SNPs) in the MTNR1B gene and fasting glucose levels in a Korean population consisting of 8,229 subjects taken from two community-based cohorts. The mean age of the subjects in the study population was 51.9 years. For this study, we selected 363 SNPs located in the MTNR1B gene, which is located on chromosome 11. Multivariate linear regression models were used to test for genotypic effects on fasting glucose levels while adjusting for age and sex under an additive model. The MTNR1B SNP most highly associated with fasting glucose levels was rs10830962 (p=1.95×10−5), followed by rs3847554 (p=3.16×10−4). Replication of these initial findings is important to better understand the correlation between MTNR1B variations and their effects, especially in Asian populations.

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Authors and Affiliations

  1. Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Sungnam-Si, Gyeongi-Do, 461-713, Korea

    Ho Joong Sung & Jae Woong Sull

  2. Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea

    Mee Kyung Jung & Sun Ha Jee

  3. Department of Biomedical Laboratory Science, Korea Nazarene University, Cheonan, 330-718, Korea

    Yong-Bin Eom

  4. DNA Link, Inc., Seoul, Korea

    Jong-Eun Lee

Authors
  1. Ho Joong Sung
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  2. Mee Kyung Jung
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  3. Yong-Bin Eom
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  4. Jong-Eun Lee
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  5. Jae Woong Sull
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  6. Sun Ha Jee
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Correspondence to Jae Woong Sull.

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Sung, H.J., Jung, M.K., Eom, YB. et al. Effects of MTNR1B variants on fasting glucose levels in a Korean population. Genes Genom 34, 103–106 (2012). https://doi.org/10.1007/s13258-011-0097-y

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  • DOI: https://doi.org/10.1007/s13258-011-0097-y

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