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Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus

  • Virology
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Abstract

The ethanol extract of Zanthoxylum piperitum (L.) DC. showed in vitro antiviral activity against influenza A virus. Three flavonol glycosides were isolated from the EtOAc fraction of Z. piperitum leaf by means of activity-guided chromatographic separation. Structures of isolated compounds were identified as quercetin 3-O-β-D-galactopyranoside (1), quercetin 3-O-α-L-rhamnopyranoside (2), kaempferol 3-O-α-L-rhamnopyranoside (3) by comparing their spectral data with literature values. The anti-influenza viral activity of isolates was evaluated using a plaque reduction assay against influenza A/NWS/33 (H1N1) virus. The compounds also were subjected to neuraminidase inhibition assay in influenza A/NWS/33 virus. Compounds 1–3 exhibited antiviral activity against an influenza A virus in vitro, and inhibited the neuraminidase activity at relatively high concentrations.

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Authors and Affiliations

  1. School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Republic of Korea

    Song-Yi Ha, Hee Tae Kim, Kwang Min Lee, Tae Hoon Eom, In Su Kim & Jong Hwan Kwak

  2. College of Veterinary Medicine, Konkuk University, Seoul, 143-701, Republic of Korea

    Hana Youn & Chang-Seon Song

  3. Department of Life Science, Gachon University, Sungnam, 461-701, Republic of Korea

    Se Chan Kang

  4. Department of Oriental Pharmacy, Woosuk University, Jeonju, 565-701, Republic of Korea

    Jong Jin Bae

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  1. Song-Yi Ha
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  2. Hana Youn
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Correspondence to Jong Hwan Kwak.

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Ha, SY., Youn, H., Song, CS. et al. Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus. J Microbiol. 52, 340–344 (2014). https://doi.org/10.1007/s12275-014-4073-5

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  • DOI: https://doi.org/10.1007/s12275-014-4073-5

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