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Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India

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Abstract

Human reproduction is considered as the most inefficient event as ∼15–20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in couples with recurrent miscarriages in the region of Punjab and to compare with worldwide frequencies. In this study, a total of 440 cases were referred between the period 1995–2015. After lymphocyte culturing, giemsa–trypsin banding was done for each case to assess the chromosomal anomalies. The frequency of chromosomal aberrations among couples was found to be 3.41% in our study. Among these aberrations, balanced reciprocal translocations formed the largest group with 60% anomalies. We would conclude that clinicians should understand the importance of chromosomal analysis in these couples and refer them for karyotyping after two miscarriages to rule out the possible genetic cause of recurrent miscarriages.

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Acknowledgements

We thank the Department of Science and Technology for providing financial assistance and fellowship to Ms Neha Sudhir, through DST-PURSE. We also acknowledge Ms Amandeep Kaur for providing practical help while preparing cytogenetic report of patients.

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Authors and Affiliations

  1. Department of Human Genetics, Guru Nanak Dev University, Amritsar, 143 005, India

    NEHA SUDHIR & ANUPAM KAUR

  2. Hartej Hospital and Nursing Home, Amritsar, 143 005, India

    TAJINDER KAUR

  3. Beri Maternity Hospital, Southend Beri Fertility and IVF, Amritsar, 143 005, India

    ARCHANA BERI

Authors
  1. NEHA SUDHIR
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  2. TAJINDER KAUR
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  3. ARCHANA BERI
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  4. ANUPAM KAUR
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Corresponding author

Correspondence to ANUPAM KAUR.

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Corresponding editor: Arun Kumar

[Sudhir N., Kaur T., Beri A. and Kaur A. 2016 Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India. J. Genet. 95, xx–xx]

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SUDHIR, N., KAUR, T., BERI, A. et al. Cytogenetic analysis in couples with recurrent miscarriages: a retrospective study from Punjab, north India. J Genet 95, 887–894 (2016). https://doi.org/10.1007/s12041-016-0713-3

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