Abstract
Although previous studies showed the reduced risk of cancer in patients with schizophrenia, whether patients with schizophrenia possess genetic factors that also contribute to tumor suppressor is still unknown. In the present study, based on our previous microarray data, we focused on the tumor suppressor genes TXNIP and AF1q, which differentially expressed in patients with schizophrenia. A total of 413 patients and 578 healthy controls were recruited. We found no significant differences in genotype, allele, or haplotype frequencies at the selected five single nucleotide polymorphisms (SNPs) (rs2236566 and rs7211 in TXNIP gene; rs10749659, rs2140709, and rs3738481 in AF1q gene) between patients with schizophrenia and controls. However, we found the association between the interaction of TXNIP and AF1q with schizophrenia by using the MDR method followed by traditional statistical analysis. The best gene-gene interaction model identified was a three-locus model TXNIP (rs2236566, rs7211)-AF1q (rs2140709). After traditional statistical analysis, we found the high-risk genotype combination was rs2236566 (GG)-rs7211(CC)-rs2140709(CC) (OR = 1.35 [1.03–1.76]). The low-risk genotype combination was rs2236566 (GT)-rs7211(CC)-rs2140709(CC) (OR = 0.67 [0.49–0.91]). Our finding suggested statistically significant role of interaction of TXNIP and AF1q polymorphisms (TXNIP-rs2236566, TXNIP-rs7211, and AF1q-rs2769605) in schizophrenia susceptibility.
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Acknowledgments
The authors are very grateful to all participants. We thank Drs. Liwei Liao, Zheng Chen, and Ying Qiao for help with sample collection.
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All procedures were reviewed and approved by Institutional Review Boards of Shanghai Mental Health Center.
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This study was supported by the National Natural Science Foundation of China (81401127, 81171266, 81271481), Shanghai Natural Science Foundation (13ZR1460500), Shanghai Municipal Commission of health and Family Planning Found (Zezhi Li), and Shanghai Key Laboratory of Psychotic Disorders (13dz2260500,14-K06). All funding for this study had no further role in study design, data analysis, and in the decision to submit the paper for publication. The authors declare no conflict of interest.
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Yousong Su and Wenhua Ding contributed equally to the work.
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Su, Y., Ding, W., Xing, M. et al. The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia. Mol Neurobiol 54, 4806–4812 (2017). https://doi.org/10.1007/s12035-016-9954-7
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DOI: https://doi.org/10.1007/s12035-016-9954-7